alpha-Lactose

Base Information

• Chemical Name: alpha-Lactose
• CAS No.: 14641-93-1
• Molecular Formula: C₁₂H₂₂O₁₁
• Molecular Weight: 342.3
• Hs Code.: 29400090
• European Community (EC) Number: 238-691-8
• NSC Number: 760401
• UNII: MJF4JAT10B
• DSSTox Substance ID: DTXSID50873004
• Nikkaji Number: J241.337J
• Wikidata: Q27104342
• RXCUI: 2359362
• Metabolomics Workbench ID: 37122
• Mol file: 14641-93-1.mol

Synonyms:Anhydrous Lactose;Lactose;Lactose, Anhydrous

Chemical Property of alpha-Lactose

Chemical Property:

• Appearance/Colour: White fine crystals
• Vapor Pressure: 1.08E-20mmHg at 25°C
• Melting Point: 201-202 °C
• Refractive Index: 52.5 ° (C=10, H2O)
• Boiling Point: 667.9 °C at 760 mmHg
• PKA: 12.02±0.70(Predicted)
• Flash Point: 357.8 °C
• PSA: 189.53000
• Density: 1.76 g/cm³
• LogP: -5.39720
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: -4.7
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 4
• Exact Mass: 342.11621151
• Heavy Atom Count: 23
• Complexity: 382

Purity/Quality:

98%,99%, ^*data from raw suppliers

ALPHA-LACTOSE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)O)CO)O)O)O)O
• Isomeric SMILES: C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@@H]([C@@H]([C@H]2O)O)O)CO)O)O)O)O

Technology Process of alpha-Lactose

There total 10 articles about alpha-Lactose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

D-Glucose (2280-44-6) + β‐cyclodextrin (7585-39-9) + maltotriose (6401-81-6,17659-52-8,19141-16-3,20702-55-0,52485-13-9,69429-19-2,80446-86-2,80446-87-3,94799-30-1,94799-74-3,113158-51-3,118396-93-3,121153-20-6,133267-59-1,1109-28-0,142185-35-1) + maltopentaose (1668-09-3) + malto-octaose (4202-44-2)

Guidance literature:

In water; at 40 ℃; for 6h; Further byproducts given; cyclomaltodextrinase (534U);

DOI:10.1016/0008-6215(96)00083-3

Reference yield:

2-chloro-4-nitrophenol-α-D-maltotrioside (118291-90-0,157381-11-8,165522-16-7) → Maltose + maltotriose (6401-81-6,17659-52-8,19141-16-3,20702-55-0,52485-13-9,69429-19-2,80446-86-2,80446-87-3,94799-30-1,94799-74-3,113158-51-3,118396-93-3,121153-20-6,133267-59-1,1109-28-0,142185-35-1) + 2-chloro-4-nitrophenol (619-08-9)

Guidance literature:

With human pancreatic α-amylase; In phosphate buffer; at 30 ℃; for 0.333333h; pH=6.9; Kinetics; Enzymatic reaction;

DOI:10.1016/j.carres.2004.05.019

Reference yield:

4-nitrophenyl α-D-galactoside (7493-95-0) + melibiose (499-40-1,554-91-6,585-99-9,4233-70-9,5077-31-6,5188-47-6,6614-35-3,7286-49-9,13117-25-4,17296-19-4,19940-03-5,20113-42-2,21216-58-0,25538-26-5,28447-39-4,34097-00-2,40246-35-3,40592-71-0,52611-34-4,71184-87-7,77881-87-9,96844-88-1,117249-74-8,117249-83-9,117249-87-3,117249-92-0,117249-96-4,117250-05-2,117250-10-9,117250-14-3,117250-19-8,117306-23-7,117306-27-1,117306-32-8,117306-37-3,117306-42-0,117306-47-5,117469-04-2,117469-05-3,117469-10-0) → α-D-galactopyranose (3646-73-9) + 6-O-β-D-galactopyranosyl-D-galactose (902-54-5) + O-(α-D-galactopyranosyl)-(1->4)-D-galactopyranoside + 4-nitrophenyl (α-D-galactopyranosyl)-(1->6)-α-D-galactopyranoside (187394-28-1,335193-88-9)

Guidance literature:

at 20 ℃; Enzymatic reaction;

DOI:10.3390/md16100349

upstream raw materials:

p-nitrophenyl β-D-cellobioside

D-Glucose

β‐cyclodextrin

maltotriose