2-(2-Ethoxyethyl)pyridine

Base Information

• Chemical Name: 2-(2-Ethoxyethyl)pyridine
• CAS No.: 28672-54-0
• Molecular Formula: C9H13NO
• Molecular Weight: 151.208
• Hs Code.: 2933399090
• European Community (EC) Number: 249-140-6
• NSC Number: 163912
• UNII: X9650F9KG5
• DSSTox Substance ID: DTXSID30182828
• Nikkaji Number: J250.754D
• Wikidata: Q83053532
• Mol file: 28672-54-0.mol

Synonyms:2-(2-Ethoxyethyl)pyridine;28672-54-0;Pyridine, 2-(2-ethoxyethyl)-;X9650F9KG5;EINECS 249-140-6;NSC-163912;3-oxapentylpyridine;NSC163912;C(COCC)c1ccccn1;UNII-X9650F9KG5;SCHEMBL2093165;DTXSID30182828;MFCD00023548;AKOS006228966;CS-W018112;NSC 163912;CS-17378;FT-0608465;D72160;A819529;J-505608

Chemical Property of 2-(2-Ethoxyethyl)pyridine

Chemical Property:

• Vapor Pressure: 0.434mmHg at 25°C
• Refractive Index: 1.491
• Boiling Point: 201.6 °C at 760 mmHg
• PKA: 5.36±0.12(Predicted)
• Flash Point: 72.5 °C
• PSA: 22.12000
• Density: 0.976 g/cm³
• LogP: 1.66060
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 151.099714038
• Heavy Atom Count: 11
• Complexity: 95.6

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-ethoxyethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOCCC1=CC=CC=N1

Technology Process of 2-(2-Ethoxyethyl)pyridine

There total 8 articles about 2-(2-Ethoxyethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) + sodium ethanolate (141-52-6) → 2-(2-ethoxyethyl)pyridine (28672-54-0)

Guidance literature:

In ethanol; for 72h;

DOI:10.1021/ja0539138

Reference yield:

2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) + ethanol (64-17-5) → 2-Ethylpyridine (100-71-0) + 2-(2-ethoxyethyl)pyridine (28672-54-0)

Guidance literature:

With hydrogenchloride; for 2h; Ambient temperature; Irradiation;

DOI:10.1246/bcsj.66.1580

Reference yield:

3-(ethoxy)propionitrile (2141-62-0) + acetylene (74-86-2,25067-58-7) → 2-(2-ethoxyethyl)pyridine (28672-54-0) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1)

Guidance literature:

With triethylaluminum; cobalt(II) 2-ethylhexanoate; In toluene; at 150 ℃; for 10h; Yield given. Yields of byproduct given; autoclave;

DOI:10.1007/BF00515642

upstream raw materials:

2-vinylpyridine

ethanol

sodium ethanolate

acetone

Refernces

• 1、 Alunni, Sergio,De Angelis, Filippo,Ottavi, Laura,Papavasileiou, Magdalini,Tarantelli, Francesco. "Evidence of a borderline region between E1cb and E2 elimination reaction mechanisms: A combined experimental and theoretical study of systems activated by the pyridine ring". . p. 15151 - 15160. Retrieved 2007/10/03.
• 2、 Selimov, F. A.,Khafizov, V. R.,Dzhemilev, U. M.. "SYNTHESIS OF FUNCTIONALLY SUBSTITUTED PYRIDINES AND DIPYRIDYL-SUBSTITUTED COMPOUNDS WITH THE AID OF LOW-VALENCE COMPOLEXES". . p. 290 - 295. Retrieved 2007/10/02.