Acetic acid, [(phenylmethyl)sulfonyl]-, ethyl ester

Base Information

• Chemical Name: Acetic acid, [(phenylmethyl)sulfonyl]-, ethyl ester
• CAS No.: 29771-81-1
• Molecular Formula: C11H14O4S
• Molecular Weight: 242.296
• Mol file: 29771-81-1.mol

Synonyms:Benzylsulfon-essigsaeure-aethylester;phenylmethanesulfonyl-acetic acid ethyl ester;Aethyl-benzylsulfonylacetat;Phenylmethansulfonyl-essigsaeure-aethylester;ethyl benzylsulfonylacetate;ethyl 2-benzylsulfonylacetate;

Chemical Property of Acetic acid, [(phenylmethyl)sulfonyl]-, ethyl ester

Chemical Property:

• PSA: 68.82000
• LogP: 2.24530

Purity/Quality:

99% ^*data from raw suppliers

Ethyl-2-benzylsulfonylacetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetic acid, [(phenylmethyl)sulfonyl]-, ethyl ester

There total 7 articles about Acetic acid, [(phenylmethyl)sulfonyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl (benzylthio)acetate (2899-67-4) → benzyl carbethoxymethyl sulfone (29771-81-1)

Guidance literature:

With 1,9-diperoxynonanedioic acid; In acetonitrile; at 30 - 32 ℃; for 0.333333h; Solvent; Temperature;

DOI:10.1039/c5nj02616d

Reference yield: 83.0%

diazoacetic acid ethyl ester (623-73-4) + benzylsulfonylhydrazide (36331-57-4) → benzyl carbethoxymethyl sulfone (29771-81-1)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In isopropyl alcohol; at 80 ℃; for 24h;

DOI:10.1021/acs.orglett.6b02532

Reference yield: 80.0%

ethyl (benzylthio)acetate (2899-67-4) → benzyl carbethoxymethyl sulfone (29771-81-1) + benzyl ethoxycarbonylmethyl sulfoxide (108499-38-3)

Guidance literature:

With dihydrogen peroxide; titanium(IV) oxide; In acetonitrile; at 20 ℃; for 10h;

DOI:10.1016/j.molcata.2010.03.011

upstream raw materials:

ethyl (benzylthio)acetate

ethanol

S-benzylisothiourea hydrochloride

chloroacetic acid

Downstream raw materials:

α-Benzylsulfonylzimtsaeureethylester

α-Benzylsulfonylhydrozimtsaeureethylester

N--urethan

ethyl α-(benzylsulfonyl)diazoacetate

Refernces

• 1、 Fu, Ying,Xu, Qin-Shan,Li, Quan-Zhou,Du, Zhengyin,Wang, Ke-Hu,Huang, Danfeng,Hu, Yulai. "Efficient synthesis of aliphatic sulfones by Mg mediated coupling reactions of sulfonyl chlorides and aliphatic halides". supporting information. p. 2841 - 2845. Retrieved 2017/04/03.
• 2、 Wang, Yaxiong,Ma, Liang,Ma, Meihua,Zheng, Hao,Shao, Ying,Wan, Xiaobing. "Bu4NI-Catalyzed Cross-Coupling between Sulfonyl Hydrazides and Diazo Compounds to Construct β-Carbonyl Sulfones Using Molecular Oxygen". supporting information. p. 5082 - 5085. Retrieved 2016/10/14.