6-Chloro-4-phenyl-1,2-dihydroquinolin-2-one

Base Information

Chemical Name:6-Chloro-4-phenyl-1,2-dihydroquinolin-2-one
CAS No.:30169-33-6
Molecular Formula:C15H10ClNO
Molecular Weight:255.703
Hs Code.:
European Community (EC) Number:827-684-0
Nikkaji Number:J1.350.904B
ChEMBL ID:CHEMBL452292
Mol file:30169-33-6.mol

Synonyms:6-chloro-4-phenyl-1,2-dihydroquinolin-2-one;30169-33-6;6-chloro-4-phenylquinolin-2(1H)-one;6-chloro-4-phenyl-1H-quinolin-2-one;CBMicro_009865;CBMicro_020424;Cambridge id 5139049;Oprea1_055095;MLS001173202;CHEMBL452292;SCHEMBL8987089;6-chloro-4-phenyl-2-quinolone;HMS2866M21;CCG-5051;SMSF0011584;6-Chlor-2-hydroxy-4-phenylchinolin;MFCD00545821;STK207196;AKOS002318456;AKOS030513809;CB12721;CCG-274283;AS-65979;SMR000539026;BIM-0009822.P001;BIM-0020405.P001;CS-0216482;EN300-44837;W13398;Z274770784

Suppliers and Price of 6-Chloro-4-phenyl-1,2-dihydroquinolin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 6-Chloro-4-phenyl-1,2-dihydroquinolin-2-one

Chemical Property:

Melting Point:253-254 °C
Boiling Point:454.4±45.0 °C(Predicted)
PKA:10.38±0.70(Predicted)
PSA：32.86000
Density:1.303±0.06 g/cm3(Predicted)
LogP:3.84850
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:255.0450916
Heavy Atom Count:18
Complexity:360

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CC(=O)NC3=C2C=C(C=C3)Cl

Technology Process of 6-Chloro-4-phenyl-1,2-dihydroquinolin-2-one

There total 44 articles about 6-Chloro-4-phenyl-1,2-dihydroquinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: tert-butyl (6-chloro-4-phenylquinolin-2-yl)carbonate

: 30169-33-6
6-Chlor-1,2-dihydro-4-phenylchinolin-2-on

Guidance literature:: With sulfuric acid; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;
DOI:10.1021/acs.joc.6b00519

Reference yield: 96.0%

: 719-59-5
5-chloro-2-aminobenzophenone

: 141-78-6
ethyl acetate

: 30169-33-6
6-Chlor-1,2-dihydro-4-phenylchinolin-2-on

Guidance literature:: 5-chloro-2-aminobenzophenone; ethyl acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With water; In tetrahydrofuran; at 25 ℃; for 2h;
DOI:10.1016/S0040-4039(03)00889-X