Thieno[2,3-b]pyridine-2-carboxylic acid, 3-amino-4-phenyl-6-(2-thienyl)-, ethyl ester

Base Information

• Chemical Name: Thieno[2,3-b]pyridine-2-carboxylic acid, 3-amino-4-phenyl-6-(2-thienyl)-, ethyl ester
• CAS No.: 301847-02-9
• Molecular Formula: C20H16N2O2S2
• Molecular Weight: 380.48300
• Mol file: 301847-02-9.mol

Synonyms:3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid ethyl ester;Ethyl 3-amino-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridine-2-carboxylate;

Chemical Property of Thieno[2,3-b]pyridine-2-carboxylic acid, 3-amino-4-phenyl-6-(2-thienyl)-, ethyl ester

Chemical Property:

• Melting Point: 182 °C (CHCl3)
• PSA: 121.69000
• LogP: 6.03190

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thieno[2,3-b]pyridine-2-carboxylic acid, 3-amino-4-phenyl-6-(2-thienyl)-, ethyl ester

There total 6 articles about Thieno[2,3-b]pyridine-2-carboxylic acid, 3-amino-4-phenyl-6-(2-thienyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 2-((3-cyano-4-phenyl-6-(thiophen-2-yl)pyridin-2-yl)thio)acetate (847976-22-1) → ethyl 3-amino-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridine-2-carboxylate (301847-02-9)

Guidance literature:

With sodium ethanolate; In ethanol; for 0.0833333h; Heating;

DOI:10.1080/10426500490467147

Reference yield:

2-Acetylthiophene (88-15-3,97511-16-5) + chloroacetic acid ethyl ester (105-39-5) → ethyl 3-amino-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridine-2-carboxylate (301847-02-9)

Guidance literature:

With benzaldehyde;

Reference yield:

3-phenyl-1-thiophen-2-yl-propenone (3988-77-0,39078-33-6,69656-36-6) → ethyl 3-amino-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridine-2-carboxylate (301847-02-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 43 percent / piperidine / ethanol / 4 h / Heating

2: 95 percent / sodium acetate trihydrate / ethanol / 2 h / Heating

3: 90 percent / NaOEt / ethanol / 0.08 h / Heating

With piperidine; sodium ethanolate; sodium acetate; In ethanol;

DOI:10.1080/10426500490467147

upstream raw materials:

ethyl 2-((3-cyano-4-phenyl-6-(thiophen-2-yl)pyridin-2-yl)thio)acetate

3-phenyl-1-thiophen-2-yl-propenone

4-phenyl-6-(thiophen-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile

2-Acetylthiophene

Downstream raw materials:

3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide