1-Phenyl-2,3-dihydro-1H-1lambda~5~-phosphindol-1-one

Base Information

• Chemical Name: 1-Phenyl-2,3-dihydro-1H-1lambda~5~-phosphindol-1-one
• CAS No.: 31236-96-1
• Molecular Formula: C14H13OP
• Molecular Weight: 228.23
• DSSTox Substance ID: DTXSID80501929
• Nikkaji Number: J3.287.431B
• Mol file: 31236-96-1.mol

Synonyms:31236-96-1;1-Phenyl-2,3-dihydro-1H-1lambda~5~-phosphindol-1-one;DTXSID80501929

Chemical Property of 1-Phenyl-2,3-dihydro-1H-1lambda~5~-phosphindol-1-one

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 228.070402032
• Heavy Atom Count: 16
• Complexity: 293

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CP(=O)(C2=CC=CC=C21)C3=CC=CC=C3

Technology Process of 1-Phenyl-2,3-dihydro-1H-1lambda~5~-phosphindol-1-one

There total 22 articles about 1-Phenyl-2,3-dihydro-1H-1lambda~5~-phosphindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

P,P-dichlorophenylphosphine oxide (824-72-6) + 1-bromo-2-(2-chloro-ethyl)benzene (75534-18-8) → 1-phenyl-2,3-dihydrobenzo[b]phosphole-1-oxide (31236-96-1)

Guidance literature:

1-bromo-2-(2-chloro-ethyl)benzene; With magnesium; In tetrahydrofuran; at 20 - 65 ℃; for 2h; Inert atmosphere;

P,P-dichlorophenylphosphine oxide; In tetrahydrofuran; at -78 - 20 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.joc.5b01476

Reference yield: 80.0%

trans-3a,7a-dihydrophosphindole 1-oxide (86863-35-6,86940-55-8) → 1-phenyl-2,3-dihydrobenzo[b]phosphole-1-oxide (31236-96-1)

Guidance literature:

With sodium hydroxide; for 10h; Ambient temperature;

DOI:10.1021/ja00275a044

Reference yield: 76.0%

1-phenyl-1-benzophosphole 1-oxide (31236-97-2) → 1-phenyl-2,3-dihydrobenzo[b]phosphole-1-oxide (31236-96-1)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; for 48h;

DOI:10.1021/jo401318g

upstream raw materials:

1,syn-8-Diphenyl-3a,4,7,7a-tetrahydro-4,7-phosphinidene-1(H)-phosphindole 1,8-Dioxide

1-oxo-2,3-dihydro-1H-1λ⁵-phosphindol-1-ol

1-phenyl-2,3-dihydrobenzo[b]phosphole

Phenyl-cis-2-styrylphosphine

Downstream raw materials:

1-phenyl-1-benzophosphole 1-oxide

1-phenyl-2,3-dihydrobenzo[b]phosphole

1,3,4-Triphenyl-1H-phosphindolo[3,2-c]pyrazole 4-oxide

(3aS,4S,8bR)-1,3,4-Triphenyl-3a,8b-dihydro-1H-phosphindolo[3,2-c]pyrazole 4-oxide