YM-758 monophosphate

Base Information

Chemical Name:YM-758 monophosphate
CAS No.:312752-86-6
Molecular Formula:C₂₆H₃₂FN₃O₄*H₃O₄P
Molecular Weight:567.551
Hs Code.:
UNII:64S4O9325D
DSSTox Substance ID:DTXSID10858574
Mol file:312752-86-6.mol

Synonyms:YM-758 monophosphate;312752-86-6;YM758 Phosphate;YM-758 phosphate;YM758 monophosphate;64S4O9325D;UNII-64S4O9325D;(-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide monophosphate;YM 758 Phosphate;(-)-N-(2-((R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino)ethyl)-4-fluorobenzamide monophosphate;(R)-(-)-N-(2-(3-((6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl)piperidino)ethyl)-4-fluorobenzamide monophosphate;YM 758 monophosphate;SCHEMBL3996517;DTXSID10858574;ZYPKBNXZBIMKAY-VEIFNGETSA-N;YM-758 MONOPHOSPHATE SALT;N-[2-[(3R)-3-(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)piperidin-1-yl]ethyl]-4-fluorobenzamide;phosphoric acid;AKOS040749822;J-018354;Q27263782

Suppliers and Price of YM-758 monophosphate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
YM758Phosphate
50mg
$ 1230.00

Total 2 raw suppliers

Chemical Property of YM-758 monophosphate

Chemical Property:

PSA：168.85000
LogP:3.70020
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:7
Exact Mass:567.21458024
Heavy Atom Count:39
Complexity:737

Purity/Quality:

97% ^*data from raw suppliers

YM758Phosphate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2CN(CCC2=C1)C(=O)C3CCCN(C3)CCNC(=O)C4=CC=C(C=C4)F)OC.OP(=O)(O)O
Isomeric SMILES:COC1=C(C=C2CN(CCC2=C1)C(=O)[C@@H]3CCCN(C3)CCNC(=O)C4=CC=C(C=C4)F)OC.OP(=O)(O)O
Recent EU Clinical Trials:A RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED STUDY TO EVALUATE THE SAFETY, TOLERABILITY AND PRELIMINARY EFFICACY OF A FOUR-WEEK TREATMENT WITH YM758 IN SUBJECTS WITH STABLE ANGINA.
Uses YM758 is a novel If channel inhibitor for the treatment of stable angina and atrial fibrillation. YM758 is a novel If channel inhibitor for the treatment of stable angina and atrial fibrillation. A novel cardiovascular agent.

Technology Process of YM-758 monophosphate

There total 8 articles about YM-758 monophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 312752-85-5
[14C]-YM₇₅₈

: 312752-86-6
[3H]-YM₇₅₈ monophosphate

Guidance literature:

Reference yield:

: 721452-55-7
YM-234903

: 1745-07-9
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 312752-86-6
[3H]-YM₇₅₈ monophosphate

Guidance literature:: YM-234903; 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 10 - 20 ℃; for 3h;

With phosphoric acid; In ethanol; water; at 20 ℃; for 72h; Product distribution / selectivity;

Reference yield:

: 721452-45-5
2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethylamine

: 403-43-0
4-fluorobenzoyl chloride

: 312752-86-6
[3H]-YM₇₅₈ monophosphate

Guidance literature:: 2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethylamine; 4-fluorobenzoyl chloride; In acetonitrile; at 0 - 20 ℃; for 4h;

With sodium hydrogencarbonate; In water; acetonitrile; for 0.333333h;

With phosphoric acid; In ethanol; water; Product distribution / selectivity;