N-(4-Methoxyphenyl)-3-MethylbenzaMide, 97%

Base Information

• Chemical Name: N-(4-Methoxyphenyl)-3-MethylbenzaMide, 97%
• CAS No.: 313367-17-8
• Molecular Formula: C15H15NO2
• Molecular Weight: 241.29
• Mol file: 313367-17-8.mol

Synonyms:N-(4-Methoxyphenyl)-3-methylbenzamide;

Chemical Property of N-(4-Methoxyphenyl)-3-MethylbenzaMide, 97%

Chemical Property:

• PSA: 38.33000
• LogP: 3.32890

Purity/Quality:

99% ^*data from raw suppliers

N-(4-METHOXY-PHENYL)-3-METHYL-BENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-Methoxyphenyl)-3-MethylbenzaMide, 97%

There total 10 articles about N-(4-Methoxyphenyl)-3-MethylbenzaMide, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C22H22N2O3 + 4-methoxy-aniline (104-94-9) → N-(4-methoxyphenyl)-3-methylbenzamide (313367-17-8)

Guidance literature:

With [(1,2,3-N)-3-phenyl-2-propenyl][1,3-bis(2,6-diisopropylbenzene)-4,5-dihydroimidazol-2-yl]palladium chloride; potassium carbonate; In tetrahydrofuran; at 110 ℃; for 24h; Schlenk technique; Inert atmosphere;

Reference yield: 92.0%

m-toluamide (618-47-3) + 4-chloromethoxybenzene (623-12-1) → N-(4-methoxyphenyl)-3-methylbenzamide (313367-17-8)

Guidance literature:

With tri(sec-butyl)borane; (DiMeIHeptCl)Pd(cinammyl)Cl; caesium carbonate; In toluene; at 90 ℃; for 24h; Reagent/catalyst; Temperature; Inert atmosphere; Sealed tube; Schlenk technique;

DOI:10.1021/jacs.7b09488

Reference yield: 83.0%

m-toluamide (618-47-3) + 4-chloromethoxybenzene (623-12-1) → N-(4-methoxyphenyl)-3-methylbenzamide (313367-17-8) + methoxybenzene (100-66-3)

Guidance literature:

With C₆₀H₉₁Cl₃N₂Pd; sodium 2,6-di-tert-butyl-4-methylphenoxide; In toluene; at 80 ℃; for 24h; Solvent; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201902876

upstream raw materials:

m-toluamide

para-iodoanisole

4-methoxy-aniline

3-Methylbenzoyl chloride

Downstream raw materials:

6-methoxy-2-(m-tolyl)benzo[d]oxazole

C₁₅H₁₄ClNO

4-(4-methoxyphenyl)-3-(4-nitrophenyl)-5-m-tolyl-4H-[1,2,4]triazole

4-[4-(4-methoxyphenyl)-5-m-tolyl-4H-[1,2,4]triazol-3-yl]pyridine

Refernces

• 1、 Wu, Wengang,Yi, Jun,Xu, Huipeng,Li, Shuangjun,Yuan, Rongxin. "An efficient, one-pot transamidation of 8-aminoquinoline amides activated by tertiary-butyloxycarbonyl". . . Retrieved 2019/04/05.
• 2、 Hari Balakrishnan, Madasamy,Sathriyan, Kotturaja,Mannathan, Subramaniyan. "Nickel-Catalyzed Denitrogenative Cross-Coupling Reaction of 1,2,3-Benzotriazin-4(3 H)-ones with Organoboronic Acids: An Easy Access to Ortho-Arylated and Alkenylated Benzamides". supporting information. p. 3815 - 3818. Retrieved 2018/07/25.