37085-48-6 Usage
General Description
2-O-Methylthymidine is a nucleoside, a type of chemical compound found in DNA, composed of the nucleobase thymine and the sugar deoxyribose with an additional methyl group attached at the 2' position of the ribose ring. It is commonly used as a biochemical marker for the presence of viral infections, serving as a biomarker for certain diseases. Additionally, 2-O-Methylthymidine has been studied for its potential use in anti-cancer drug development, as it shows promise in inhibiting tumor growth and inducing cell death in cancer cells. This chemical compound has potential applications in both diagnostic and therapeutic settings within the field of medicine and pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 37085-48-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,0,8 and 5 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 37085-48:
(7*3)+(6*7)+(5*0)+(4*8)+(3*5)+(2*4)+(1*8)=126
126 % 10 = 6
So 37085-48-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H16N2O5/c1-6-4-13(11(17-2)12-10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,3,5H2,1-2H3/t7-,8+,9+/m0/s1
37085-48-6Relevant articles and documents
A novel synthesis of 3'-deoxy-3'-nitrothymidine via nucleophilic substitution with nitrite anion
Huang,Ragouzeos,Rideout
, p. 691 - 695 (1995)
Nucleophilic substitution at C3' of 1-(2-deoxy-5-O-trityl-β-D-erythro-pentofuranosyl)-2-methoxy-5-methyl- 4(1H)-pyrimidinone (5) with methyl iodide/triphenylphosphine/diethyl azodicarboxylate gave the expected inverted iodide 6 and minor epimer 7. Treatment of 6 with lithium nitrite/phloroglucinol yielded the desired nitro derivative 8 and subsequent acidic deprotection afforded the title compound 1. This represents a novel method for the introduction of a nitro group into the furanosyl moiety of a nucleoside. The nmr spectroscopic techniques (COSY, NOESY, nOe, HMQC and HMBC) were used to determine the stereochemistry at C3' of the nucleosides. Spectral analysis of H-D exchange at the 3'-position of 1 did not indicate the formation of its epimer 10.
Method for preparing radiolabeled thymidine
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Sheet 3/3, (2008/06/13)
The invention is a novel method and precursor for preparing radiolabeled nucleosides. In particular, the invention is useful for preparing 3′-[18F]fluorothymidine. The method uses an enol group that is attached to the 2-position on the pyrimidi
