S-[(Diphenylphosphoryl)methyl] ethanethioate

Base Information

Chemical Name:S-[(Diphenylphosphoryl)methyl] ethanethioate
CAS No.:324753-14-2
Molecular Formula:C15H15O2PS
Molecular Weight:290.323
Hs Code.:
DSSTox Substance ID:DTXSID10545093
Wikidata:Q82422464
Mol file:324753-14-2.mol

Synonyms:324753-14-2;S-[(Diphenylphosphoryl)methyl] ethanethioate;S-(diphenylphosphorylmethyl) ethanethioate;(Mercaptomethyl)diphenylphosphine Oxide S-Acetate;Ethanethioic Acid S-[(Diphenylphosphinyl)methyl] Ester;DTXSID10545093;J-018749

Suppliers and Price of S-[(Diphenylphosphoryl)methyl] ethanethioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(Mercaptomethyl)diphenylphosphineOxideS-Acetate
50mg
$ 155.00

TRC
(Mercaptomethyl)diphenylphosphineOxideS-Acetate
500mg
$ 1230.00

American Custom Chemicals Corporation
(MERCAPTOMETHYL)DIPHENYLPHOSPHINE OXIDE 95.00%
5MG
$ 500.09

Total 3 raw suppliers

Chemical Property of S-[(Diphenylphosphoryl)methyl] ethanethioate

Chemical Property:

Boiling Point:393.8±25.0 °C(Predicted)
PSA：69.25000
Density:1.22±0.1 g/cm3(Predicted)
LogP:3.23770
Solubility.:Chloroform, Dichloromethane, Ethyl Acetate
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:290.05303789
Heavy Atom Count:19
Complexity:322

Purity/Quality:

98% ^*data from raw suppliers

(Mercaptomethyl)diphenylphosphineOxideS-Acetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)SCP(=O)(C1=CC=CC=C1)C2=CC=CC=C2
Uses (MercaptoMethyl)diphenylphosphine Oxide is used for production of peptide thioester.

Technology Process of S-[(Diphenylphosphoryl)methyl] ethanethioate

There total 8 articles about S-[(Diphenylphosphoryl)methyl] ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1806-49-1
diphenyl(chloromethyl)phosphine oxide

: 507-09-5
tiolacetic acid

: 324753-14-2
S-(diphenylphosphinoyl)methyl ethanethioate

Guidance literature:: With triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 24h; Heating;
DOI:10.1021/ol006739v

Reference yield: 80.0%

: 1806-49-1
diphenyl(chloromethyl)phosphine oxide

: 10387-40-3
potassium thioacetate

: 324753-14-2
S-(diphenylphosphinoyl)methyl ethanethioate

Guidance literature:: With N,N-dimethyl-formamide;
DOI:10.1002/chem.201601807

Reference yield:

: phenylmagnesium bromide

: 324753-14-2
S-(diphenylphosphinoyl)methyl ethanethioate

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / tetrahydrofuran / 24 h / Heating

2: 85 percent / diisopropylethyl amine; triethyl amine / tetrahydrofuran / 24 h / Heating

With triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1: Grignard reaction;
DOI:10.1021/ol006739v