5-Thiazolecarboxylic acid, 2-[1-[2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)phenyl] -1-methylethyl]-4-phenyl-, 1,1-dimethylethyl ester

Base Information

Chemical Name:5-Thiazolecarboxylic acid, 2-[1-[2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)phenyl] -1-methylethyl]-4-phenyl-, 1,1-dimethylethyl ester
CAS No.:325968-64-7
Molecular Formula:C26H24Cl2N4O4S
Molecular Weight:559.473
Hs Code.:

5-Thiazolecarboxylic acid,
2-[1-[2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)phenyl]
-1-methylethyl]-4-phenyl-, 1,1-dimethylethyl ester

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Chemical Property of 5-Thiazolecarboxylic acid, 2-[1-[2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)phenyl] -1-methylethyl]-4-phenyl-, 1,1-dimethylethyl ester

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MSDS Files:: SDS file from LookChem

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Technology Process of 5-Thiazolecarboxylic acid, 2-[1-[2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)phenyl] -1-methylethyl]-4-phenyl-, 1,1-dimethylethyl ester

There total 8 articles about 5-Thiazolecarboxylic acid, 2-[1-[2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)phenyl] -1-methylethyl]-4-phenyl-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 261512-59-8
2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneethane-thioamide

: 219981-44-9
1,1-dimethylethyl α-bromo-β-oxo-benzenepropionate

: 325968-64-7
2-{1-[2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-phenyl]-1-methyl-ethyl}-4-phenyl-thiazole-5-carboxylic acid tert-butyl ester

Guidance literature:: 2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneethane-thioamide; 1,1-dimethylethyl α-bromo-β-oxo-benzenepropionate; With potassium carbonate; In acetonitrile; at 20 ℃;

In tert-butyl alcohol; Heating;
DOI:10.1021/jm049479m

Reference yield:

: 261512-47-4
2,6-dichloro-α,α-dimethyl-4-nitrobenzeneacetonitrile

: 325968-64-7
2-{1-[2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-phenyl]-1-methyl-ethyl}-4-phenyl-thiazole-5-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 15.0 g / H₂ / Raney Ni / methanol / 1 h / 20 °C / 2250.18 Torr

2.1: aq. HCl; AcOH; NaNO₂ / 1.83 h / 10 °C

2.2: 84 percent / aq. NaOAc / 0.67 h

3.1: KOAc; AcOH / 3 h / 120 °C

4.1: 100.6 g / aq. HCl / 4 h / Heating

5.1: 44 percent / thioglycolic acid / 4 h / 100 °C

6.1: 40 percent / diisopropylethylamine; H₂S; pyridine / 24 h / 80 °C

7.1: K₂CO₃ / acetonitrile / 20 °C

7.2: 50 percent / 2-methyl-propan-2-ol / Heating

With pyridine; hydrogenchloride; hydrogen sulfide; hydrogen; potassium acetate; potassium carbonate; acetic acid; mercaptoacetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; nickel; In methanol; acetonitrile;
DOI:10.1021/jm049479m

Reference yield:

: 261512-58-7
2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneacetonitrile

: 325968-64-7
2-{1-[2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-phenyl]-1-methyl-ethyl}-4-phenyl-thiazole-5-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 40 percent / diisopropylethylamine; H₂S; pyridine / 24 h / 80 °C

2.1: K₂CO₃ / acetonitrile / 20 °C

2.2: 50 percent / 2-methyl-propan-2-ol / Heating

With pyridine; hydrogen sulfide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1021/jm049479m