2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneethane-thioamide

Base Information

Chemical Name:2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneethane-thioamide
CAS No.:261512-59-8
Molecular Formula:C₁₃H₁₂Cl₂N₄O₂S
Molecular Weight:359.236
Hs Code.:

Synonyms:2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneethane-thioamide

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Chemical Property of 2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneethane-thioamide

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Technology Process of 2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneethane-thioamide

There total 6 articles about 2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneethane-thioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 261512-58-7
2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneacetonitrile

: 261512-59-8
2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneethane-thioamide

Guidance literature:: With pyridine; hydrogen sulfide; N-ethyl-N,N-diisopropylamine; at 80 ℃; for 24h;
DOI:10.1021/jm049479m

Reference yield:

: 261512-47-4
2,6-dichloro-α,α-dimethyl-4-nitrobenzeneacetonitrile

: 261512-59-8
2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneethane-thioamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 15.0 g / H₂ / Raney Ni / methanol / 1 h / 20 °C / 2250.18 Torr

2.1: aq. HCl; AcOH; NaNO₂ / 1.83 h / 10 °C

2.2: 84 percent / aq. NaOAc / 0.67 h

3.1: KOAc; AcOH / 3 h / 120 °C

4.1: 100.6 g / aq. HCl / 4 h / Heating

5.1: 44 percent / thioglycolic acid / 4 h / 100 °C

6.1: 40 percent / diisopropylethylamine; H₂S; pyridine / 24 h / 80 °C

With pyridine; hydrogenchloride; hydrogen sulfide; hydrogen; potassium acetate; acetic acid; mercaptoacetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; nickel; In methanol;
DOI:10.1021/jm049479m

Reference yield:

: 261512-57-6
2-[3,5-dichloro-4-(1-cyano-1-methylethyl)phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carboxylic acid

: 261512-59-8
2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneethane-thioamide

Guidance literature:: Multi-step reaction with 2 steps

1: 44 percent / thioglycolic acid / 4 h / 100 °C

2: 40 percent / diisopropylethylamine; H₂S; pyridine / 24 h / 80 °C

With pyridine; hydrogen sulfide; mercaptoacetic acid; N-ethyl-N,N-diisopropylamine;
DOI:10.1021/jm049479m