SCUTELLAREIN

Base Information

• Chemical Name: SCUTELLAREIN
• CAS No.: 529-53-3
• Molecular Formula: C15H10O6
• Molecular Weight: 286.241
• Hs Code.: 29329990
• Mol file: 529-53-3.mol

Synonyms:Flavone,4',5,6,7-tetrahydroxy- (7CI,8CI);Scutellarein (6CI);4',5,6,7-Tetrahydroxyflavone;6-Hydroxyapigenin;

Chemical Property of SCUTELLAREIN

Chemical Property:

• Vapor Pressure: 3.97E-17mmHg at 25°C
• Melting Point: 330°C
• Refractive Index: 1.767
• Boiling Point: 642.9°Cat760mmHg
• PKA: 6.34±0.40(Predicted)
• Flash Point: 249.9°C
• PSA: 111.13000
• Density: 1.654g/cm³
• LogP: 2.28240
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble1mg/mL, clear, greenish-yellow

Purity/Quality:

98%,99%, ^*data from raw suppliers

Scutellarein ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Description: Scutellarein is a flavone that has been isolated from S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities. It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml. Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC50s = 12 and 0.86 μM, respectively). It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM. In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.
• Uses: Scutellarein is a flavonoid that can be found in Scutellaria lateriflora. Scutellarein is a hydrolysis product of Scutellarein (S201900), its glucuronide conjugated analogue.

Technology Process of SCUTELLAREIN

There total 45 articles about SCUTELLAREIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-hydroxy-4',6,7-trimethoxyflavone (19103-54-9) → scutellarein (529-53-3)

Guidance literature:

With hydrogen bromide; acetic acid; In water;

DOI:10.1080/14786419.2011.566224

Reference yield: 96.0%

scutellarein 7-O-β-D-glucuronopyranoside methyl ester (119262-68-9) → scutellarein (529-53-3)

Guidance literature:

With sulfuric acid; In ethanol; water; at 95 ℃; for 7h; Temperature; Time; Inert atmosphere;

DOI:10.1016/j.tet.2017.02.039

Reference yield: 94.0%

5,6,7,4'-tetramethoxyflavone (1168-42-9) → scutellarein (529-53-3)

Guidance literature:

With hydrogen bromide; acetic acid; at 125 ℃; for 22h; Temperature; Inert atmosphere;

upstream raw materials:

7-hydroxy-5,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

5,6,7,4'-tetramethoxyflavone

6-demethoxytangeretin

hispidulin

Downstream raw materials:

scutellarein 7-O-glucuronopyranoside

5,6,7-trihydroxy-2-[4-(phenylmethoxy)phenyl]-4H-1-benzopyran-4-one

7-(benzyloxy)-2-(4-(benzyloxy)phenyl)-5,6-dihydroxy-4H-chromen-4-one

7-(benzyloxy)-2-(4-(benzyloxy)phenyl)-5-hydroxy-6-methoxy-4H-chromen-4-one

Refernces

• 1、 Jay,Gonnet. "-". . p. 953. Retrieved 1973.
• 2、 Sheremet,Komissarenko. "-". . . Retrieved 1971.
• 3、 Gritsenko,Litvinenko. "-". . . Retrieved 1969.
• 4、 Bandyukova,Boikova. "-". . . Retrieved 1969.
• 5、 -. "Benzoic acid nitrogen mustard fragment-containing compound and preparation method and use thereof". Paragraph 0016; 0024-0026. . Retrieved 2019/01/23.
• 6、 Karimov,Ostroushko, Yu. V.,Botirov, E. Kh.. "Flavone Glucosides from the Aerial Part of Scutellaria comosa". . p. 545 - 546. Retrieved 2019/07/02.