1,4-Bis(4-methoxyphenyl)piperazine

Base Information

Chemical Name:1,4-Bis(4-methoxyphenyl)piperazine
CAS No.:3367-51-9
Molecular Formula:C18H22N2O2
Molecular Weight:298.385
Hs Code.:
DSSTox Substance ID:DTXSID30542362
Nikkaji Number:J1.304.097D
Wikidata:Q82418996

Synonyms:1,4-Bis(4-methoxyphenyl)piperazine;3367-51-9;DTXSID30542362

Suppliers and Price of 1,4-Bis(4-methoxyphenyl)piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1,4-Bis(4-methoxyphenyl)piperazine

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:298.168127949
Heavy Atom Count:22
Complexity:283

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)N2CCN(CC2)C3=CC=C(C=C3)OC

Technology Process of 1,4-Bis(4-methoxyphenyl)piperazine

There total 8 articles about 1,4-Bis(4-methoxyphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.0%

: 110-85-0
piperazine

: 623-12-1
4-chloromethoxybenzene

: 38212-30-5
4-(4-methoxyphenyl)piperazine

: 3367-51-9
1,4-bis(4-methoxyphenyl)piperazine

Guidance literature:: piperazine; With [2,2]bipyridinyl; tert-Amyl alcohol; nickel diacetate; In tetrahydrofuran; at 63 ℃; for 2h;

4-chloromethoxybenzene; With styrene; In tetrahydrofuran; for 12h; Heating;
DOI:10.1016/S0040-4039(00)00277-X

Reference yield:

: 110-85-0
piperazine

: (4-methoxyphenyl)[[(4-methylphenyl)sulfonyl]oxy][2,4,6-tris(1-methylethyl)phenyl]-λ³-iodane

: 38212-30-5
4-(4-methoxyphenyl)piperazine

: 3367-51-9
1,4-bis(4-methoxyphenyl)piperazine

Guidance literature:: With tetrakis(acetonitrile)copper(I)tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; acetonitrile; at 40 ℃; for 12h; regioselective reaction;
DOI:10.1021/acscatal.5b01992

Reference yield:

: 110-85-0
piperazine

: 104-92-7
1-bromo-4-methoxy-benzene

: 38212-30-5
4-(4-methoxyphenyl)piperazine

: 3367-51-9
1,4-bis(4-methoxyphenyl)piperazine

: 100-66-3
methoxybenzene

Guidance literature:: With sodium t-butanolate; palladium bis(dibenzylideneacetone)palladium⁽⁰⁾; tri-tert-butyl phosphine; In o-xylene; at 120 ℃; Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4039(97)10659-1