Benzenesulfonamide, N-[4,5-dimethoxy-2-[(5-methyl-2-furanyl)phenylmethyl]phenyl]-4-methyl-

Base Information

• Chemical Name: Benzenesulfonamide, N-[4,5-dimethoxy-2-[(5-methyl-2-furanyl)phenylmethyl]phenyl]-4-methyl-
• CAS No.: 309927-65-9
• Molecular Formula: C27H27NO5S
• Molecular Weight: 477.581
• Mol file: 309927-65-9.mol

Synonyms:4,5-dimethoxy-2-[5-methyl-2-furyl(phenyl)methyl]-1-(4-methylphenylsulfonamido)benzene;N-{4,5-Dimethoxy-2-[(5-methyl-furan-2-yl)-phenyl-methyl]-phenyl}-4-methyl-benzenesulfonamide;

Chemical Property of Benzenesulfonamide, N-[4,5-dimethoxy-2-[(5-methyl-2-furanyl)phenylmethyl]phenyl]-4-methyl-

Chemical Property:

• PSA: 86.15000
• LogP: 7.04840

Purity/Quality:

N-[4,5-DIMETHOXY-2-[(5-METHYLFURAN-2-YL)-PHENYLMETHYL]PHENYL]-4-METHYLBENZENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenesulfonamide, N-[4,5-dimethoxy-2-[(5-methyl-2-furanyl)phenylmethyl]phenyl]-4-methyl-

There total 10 articles about Benzenesulfonamide, N-[4,5-dimethoxy-2-[(5-methyl-2-furanyl)phenylmethyl]phenyl]-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-methylfuran (534-22-5) + N-(4,5-dimethoxy-2-(hydroxy(phenyl)methyl)phenyl)-4-methylbenzenesulfonamide (340696-16-4) → 4-methyl-N-{4,5-dimethoxy-2-[(5-methylfuran-2-yl)(phenyl)methyl]phenyl}benzenesulfonamide (309927-65-9)

Guidance literature:

With toluene-4-sulfonic acid; In 1,2-dichloro-ethane; at 60 ℃;

DOI:10.1021/acs.orglett.6b00805

Reference yield:

2-benzoyl-4,5-dimethoxy-1-(4-methylphenylsulfonamido)benzene (309927-64-8) → 4-methyl-N-{4,5-dimethoxy-2-[(5-methylfuran-2-yl)(phenyl)methyl]phenyl}benzenesulfonamide (309927-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NaBH₄ / ethanol / Heating

2: 82 percent / p-TsOH / CH₂Cl₂ / Heating

With sodium tetrahydroborate; toluene-4-sulfonic acid; In ethanol; dichloromethane;

DOI:10.1016/j.tet.2006.10.056

Reference yield:

1,2-dimethoxybenzene (91-16-7) → 4-methyl-N-{4,5-dimethoxy-2-[(5-methylfuran-2-yl)(phenyl)methyl]phenyl}benzenesulfonamide (309927-65-9)

Guidance literature:

Multi-step reaction with 6 steps

1: AlCl₃ / benzene / 2.5 h / 55 - 60 °C

2: 83 percent / HNO₃; AcOH / 0.5 h / 0 - 20 °C

3: 90 percent / Fe; AcOH / H₂O; ethyl acetate / 6 h / Heating

4: 81 percent / pyridine / 1 h / 20 °C

5: 85 percent / NaBH₄ / ethanol / Heating

6: 82 percent / p-TsOH / CH₂Cl₂ / Heating

With pyridine; sodium tetrahydroborate; aluminium trichloride; nitric acid; iron; toluene-4-sulfonic acid; acetic acid; In ethanol; dichloromethane; water; ethyl acetate; benzene; 1: Friedel-Crafts reaction;

DOI:10.1016/j.tet.2006.10.056

upstream raw materials:

2-methylfuran

N-(4,5-dimethoxy-2-(hydroxy(phenyl)methyl)phenyl)-4-methylbenzenesulfonamide

2-benzoyl-4,5-dimethoxy-1-(4-methylphenylsulfonamido)benzene

1,2-dimethoxybenzene

Downstream raw materials:

(3E)-4-[5,6-dimethoxy-1-(4-methylphenyl)sulfonyl-3-phenyl-1H-indol-2-yl]but-3-en-2-one

4-[5,6-dimethoxy-1-(4-methylphenylsulfonyl)-3-phenyl-1H-2-indolyl]-2-butanone