8-benzyl-1-oxa-8-azaspiro[4.5]decan-2-one

Base Information

• Chemical Name: 8-benzyl-1-oxa-8-azaspiro[4.5]decan-2-one
• CAS No.: 35296-14-1
• Molecular Formula: C15H19NO2
• Molecular Weight: 245.31700
• Hs Code.: 2934999090
• Mol file: 35296-14-1.mol

Synonyms:cis-8-benzyl-1-oxa-8-azaspiro<4.5>decan-2-one;8-Benzyl-1-oxa-8-azaspiro<4.5>decan-2-on;

Chemical Property of 8-benzyl-1-oxa-8-azaspiro[4.5]decan-2-one

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 405.197oC at 760 mmHg
• Flash Point: 155.296oC
• PSA: 29.54000
• Density: 1.166g/cm3
• LogP: 2.29610

Purity/Quality:

97% ^*data from raw suppliers

8-Benzyl-1-oxa-8-azaspiro[4.5]decan-2-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-benzyl-1-oxa-8-azaspiro[4.5]decan-2-one

There total 3 articles about 8-benzyl-1-oxa-8-azaspiro[4.5]decan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde (100-52-7) + 1-oxa-8-aza-spiro[4.5]decan-2-one (167364-29-6) → cis-8-benzyl-1-oxa-8-azaspiro<4.5>decan-2-one (35296-14-1)

Guidance literature:

With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; for 14h;

Reference yield:

3-(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-propionamide (35296-24-3) → cis-8-benzyl-1-oxa-8-azaspiro<4.5>decan-2-one (35296-14-1)

Guidance literature:

With phosphoric acid; phosphorus pentoxide; at 145 ℃; for 24h;

Reference yield:

N-benzyl-1-oxa-6-azaspiro[2,5]-octane (19867-34-6) + diethyl malonate (105-53-3) → cis-8-benzyl-1-oxa-8-azaspiro<4.5>decan-2-one (35296-14-1)

Guidance literature:

With potassium hydroxide; sodium ethanolate; Yield given. Multistep reaction;

upstream raw materials:

3-(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-propionamide

N-benzyl-1-oxa-6-azaspiro[2,5]-octane

diethyl malonate

benzaldehyde