1-(4-methoxyphenyl)-3-[(4-methoxyphenyl)amino]-5-phenyl-1,5-dihydro-2H-pyrrol-2-one

Base Information

• Chemical Name: 1-(4-methoxyphenyl)-3-[(4-methoxyphenyl)amino]-5-phenyl-1,5-dihydro-2H-pyrrol-2-one
• CAS No.: 102750-04-9
• Molecular Formula: C24H22 N2 O3
• Molecular Weight: 386.45
• DSSTox Substance ID: DTXSID60382713
• Nikkaji Number: J2.367.081J
• ChEMBL ID: CHEMBL1416140
• Mol file: 102750-04-9.mol

Synonyms:1-(4-methoxyphenyl)-3-[(4-methoxyphenyl)amino]-5-phenyl-1,5-dihydro-2H-pyrrol-2-one;MLS001029672;CHEMBL1416140;DTXSID60382713;HMS2782D06;STK865467;AKOS001672821;CCG-260160;NCGC00161435-01;NCGC00161435-02;SMR000427019;SR-01000494614;SR-01000494614-1;1-(4-Methoxyphenyl)-3-(4-methoxyanilino)-5-phenyl-1H-pyrrole-2(5H)-one;1-(4-Methoxy-phenyl)-3-(4-methoxy-phenylamino)-5-phenyl-1,5-dihydro-pyrrol-2-one;3-(4-Methoxyanilino)-1-(4-methoxyphenyl)-5-phenyl-1,5-dihydro-2H-pyrrol-2-one;102750-04-9

Chemical Property of 1-(4-methoxyphenyl)-3-[(4-methoxyphenyl)amino]-5-phenyl-1,5-dihydro-2H-pyrrol-2-one

Chemical Property:

• Vapor Pressure: 3.11E-13mmHg at 25°C
• Boiling Point: 575.2°Cat760mmHg
• Flash Point: 301.7°C
• PSA: 50.80000
• Density: 1.251g/cm³
• LogP: 4.92570
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 386.16304257
• Heavy Atom Count: 29
• Complexity: 571

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NC2=CC(N(C2=O)C3=CC=C(C=C3)OC)C4=CC=CC=C4

Technology Process of 1-(4-methoxyphenyl)-3-[(4-methoxyphenyl)amino]-5-phenyl-1,5-dihydro-2H-pyrrol-2-one

There total 8 articles about 1-(4-methoxyphenyl)-3-[(4-methoxyphenyl)amino]-5-phenyl-1,5-dihydro-2H-pyrrol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

pyruvic acid methyl ester (600-22-6) + benzaldehyde (100-52-7) + 4-methoxy-aniline (104-94-9) → 1-(4-methoxyphenyl)-3-((4-methoxyphenyl)amino)-5-phenyl-1H-pyrrol-2(5H)-one (102750-04-9)

Guidance literature:

With C₁₈H₉F₂₆NO₂S₂; sodium sulfate; In acetonitrile; at 20 ℃;

DOI:10.1016/j.tetlet.2013.10.058

Reference yield: 92.0%

methyl benzylidenepyruvate (107969-78-8) + 4-methoxy-aniline (104-94-9) → 1-(4-methoxyphenyl)-3-((4-methoxyphenyl)amino)-5-phenyl-1H-pyrrol-2(5H)-one (102750-04-9)

Guidance literature:

In dichloromethane; for 4h; Heating;

DOI:10.1002/jhet.5570430421

Reference yield:

C26H28N2O4 → 1-(4-methoxyphenyl)-3-((4-methoxyphenyl)amino)-5-phenyl-1H-pyrrol-2(5H)-one (102750-04-9)

Guidance literature:

With 1-butyl-1-methylpyrrolidinium hydrogen sulfate; In ethanol; at 20 ℃;

DOI:10.1007/s11164-012-0749-9

upstream raw materials:

[4-(benzylideneamino)phenyl]methanol

2-oxo-propionic acid

methyl benzylidenepyruvate

4-methoxy-aniline