Technology Process of 6-Methyl-2,3,4,5-tetrahydro-1,1'-biphenyl
There total 13 articles about 6-Methyl-2,3,4,5-tetrahydro-1,1'-biphenyl which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diphenylzinc;
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium; di-n-butylzinc;
In
tetrahydrofuran; hexane;
at -78 ℃;
Inert atmosphere;
Schlenk technique;
Sealed tube;
cyclohex-1-en-1-yl trifluoromethane sulfonate;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1.5h;
Inert atmosphere;
Schlenk technique;
Sealed tube;
methyl iodide;
With
copper(I) trifluoromethanesolfonate toluene complex;
In
tetrahydrofuran; hexane; dichloromethane;
at 0 - 20 ℃;
for 18h;
Inert atmosphere;
Schlenk technique;
Sealed tube;
DOI:10.1002/anie.202109482
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / diethyl ether; hexane / 1 h / -50 - 0 °C
1.2: 3 h / 20 °C
2.1: di-n-butylzinc; n-butyllithium; 2,2,6,6-tetramethyl-piperidine / tetrahydrofuran; hexane / -78 °C / Inert atmosphere; Schlenk technique; Sealed tube
2.2: 1.5 h / -78 °C / Inert atmosphere; Schlenk technique; Sealed tube
2.3: 18 h / 0 - 20 °C / Inert atmosphere; Schlenk technique; Sealed tube
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium; di-n-butylzinc;
In
tetrahydrofuran; diethyl ether; hexane;
DOI:10.1002/anie.202109482
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrahydrofuran / 15 h / -78 - 20 °C
2.1: di-n-butylzinc; n-butyllithium; 2,2,6,6-tetramethyl-piperidine / tetrahydrofuran; hexane / -78 °C / Inert atmosphere; Schlenk technique; Sealed tube
2.2: 1.5 h / -78 °C / Inert atmosphere; Schlenk technique; Sealed tube
2.3: 18 h / 0 - 20 °C / Inert atmosphere; Schlenk technique; Sealed tube
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium; di-n-butylzinc;
In
tetrahydrofuran; hexane;
DOI:10.1002/anie.202109482
