Technology Process of Piperazine,
4-benzoyl-2-methyl-1-[(4-nitro-7-oxido-1H-pyrrolo[2,3-b]pyridin-3-yl)oxo
acetyl]-, (2R)-
There total 8 articles about Piperazine,
4-benzoyl-2-methyl-1-[(4-nitro-7-oxido-1H-pyrrolo[2,3-b]pyridin-3-yl)oxo
acetyl]-, (2R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: diethylaluminum chloride / CH2Cl2; hexane / 48 h / 20 °C
2: 81 percent / 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; N,N-diisopropylethylamine / dimethylformamide / 8 h / 20 °C
3: 91 percent / mCPBA / acetone / 8 h
4: HNO3; CF3CO2H / 8 h
With
nitric acid; diethylaluminium chloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one;
In
hexane; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm034082o
- Guidance literature:
-
With
nitric acid; trifluoroacetic acid;
for 8h;
DOI:10.1021/jm034082o
- Guidance literature:
-
Multi-step reaction with 5 steps
1: AlCl3 / CH2Cl2 / 8 h / 20 °C
2: 90.4 percent / K2CO3 / methanol; H2O / 8 h
3: 81 percent / 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; N,N-diisopropylethylamine / dimethylformamide / 8 h / 20 °C
4: 91 percent / mCPBA / acetone / 8 h
5: HNO3; CF3CO2H / 8 h
With
aluminium trichloride; nitric acid; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm034082o
