N-Acetyl-L-leucine ethyl ester

Base Information

• Chemical Name: N-Acetyl-L-leucine ethyl ester
• CAS No.: 1114-55-2
• Molecular Formula: C₁₀H₁₉NO₃
• Molecular Weight: 201.266
• Hs Code.: 2924199090
• Mol file: 1114-55-2.mol

Synonyms:Leucine,N-acetyl-, ethyl ester, L- (8CI); Acetyl-L-leucine ethyl ester;L-N-Acetylleucine ethyl ester; N-Acetyl-L-leucine ethyl ester; NSC 280767

Chemical Property of N-Acetyl-L-leucine ethyl ester

Chemical Property:

• Vapor Pressure: 0.000711mmHg at 25°C
• Boiling Point: 307.7°Cat760mmHg
• Flash Point: 139.9°C
• PSA: 55.40000
• Density: 0.987g/cm³
• LogP: 1.49120

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Acetyl-L-leucine ethyl ester

There total 5 articles about N-Acetyl-L-leucine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

acetic anhydride (108-24-7) + L-leucine ethyl ester hydrochloride (2743-40-0) → N-Acetyl-L-leucin-ethylester (1114-55-2)

Guidance literature:

With sodium hydroxide; at -10 ℃;

DOI:10.1016/0022-328X(83)85085-2

Reference yield:

ethyl N-acetyl-leucinate (4071-36-7) → N-Acetyl-L-leucin-ethylester (1114-55-2) + N-acetyl-O-ethyl-D-leucine (75552-78-2)

Guidance literature:

In hexane; isopropyl alcohol; at 40 ℃;

DOI:10.1021/ja00543a049

Reference yield:

L-Leucine ethyl ester (2743-60-4,75023-21-1) + acetyl chloride (75-36-5) → N-Acetyl-L-leucin-ethylester (1114-55-2)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/S1386-1425(02)00031-8

upstream raw materials:

L-leucine

ethyl N-acetyl-leucinate

acetic anhydride

L-leucine ethyl ester hydrochloride

Refernces

• 1、 Coleman, Anthony W.,Hitchcock, Peter B.,Lappert, Michael F.,Maskell, Robin K.,Mueller, Joachim H.. "ROUTES TO OPTICALLY ACTIVE ELECTRON-RICH OLEFINS (L*2) AND SOME DERIVED CARBENEMETAL COMPLEXES; X-RAY STRUCTURES OF *)(NO)(PPh3)> AND cis-*)> *=, L'*=, COD = 1,5-C8H12>". . p. C9 - C14. Retrieved 1983.
• 2、 Dobashi, Akira,Oka, Kitaro,Hara, Shoji. "Opticar Resolution of the D- and L-Amino Acid Family by Liquid-Solid Chromatography". . p. 7122 - 7123. Retrieved 2007/10/02.