Ethyl 2-oxo-4-(trimethylsilyl)but-3-ynoate

Base Information

Chemical Name:Ethyl 2-oxo-4-(trimethylsilyl)but-3-ynoate
CAS No.:379224-67-6
Molecular Formula:C9H14O3Si
Molecular Weight:198.29100
Hs Code.:
European Community (EC) Number:886-104-4
Nikkaji Number:J2.142.142A
Mol file:379224-67-6.mol

Synonyms:ETHYL 2-OXO-4-(TRIMETHYLSILYL)BUT-3-YNOATE;379224-67-6;EN300-7500375

Suppliers and Price of Ethyl 2-oxo-4-(trimethylsilyl)but-3-ynoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ETHYL 2-OXO-4-(TRIMETHYLSILYL)BUT-3-YNOATE 95.00%
5MG
$ 502.22

Total 1 raw suppliers

Chemical Property of Ethyl 2-oxo-4-(trimethylsilyl)but-3-ynoate

Chemical Property:

PSA：43.37000
LogP:0.99940
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:198.07122084
Heavy Atom Count:13
Complexity:274

Purity/Quality:

98% ^*data from raw suppliers

ETHYL 2-OXO-4-(TRIMETHYLSILYL)BUT-3-YNOATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(=O)C#C[Si](C)(C)C

Technology Process of Ethyl 2-oxo-4-(trimethylsilyl)but-3-ynoate

There total 2 articles about Ethyl 2-oxo-4-(trimethylsilyl)but-3-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 139507-52-1
monoethoxyoxalic acid N-methoxy-N-methylamide

: 1066-54-2
trimethylsilylacetylene

: 379224-67-6
trimethylsilylethynylglyoxylic acid ethyl ester

Guidance literature:: trimethylsilylacetylene; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h;

monoethoxyoxalic acid N-methoxy-N-methylamide; In diethyl ether; hexane; for 2h;
DOI:10.1002/asia.201801016

Reference yield: 69.0%

: 4755-77-5
Ethyl oxalyl chloride

: 1066-54-2
trimethylsilylacetylene

: 379224-67-6
trimethylsilylethynylglyoxylic acid ethyl ester

Guidance literature:: With copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jacs.1c00897

Reference yield: 72.0%

: 191427-03-9
(S)-2-phenyl-2,3-dihydrofuran

: 379224-67-6
trimethylsilylethynylglyoxylic acid ethyl ester

: 1353720-78-1
C₁₉H₂₆O₄Si

Guidance literature:: (S)-2-phenyl-2,3-dihydrofuran; trimethylsilylethynylglyoxylic acid ethyl ester; With titanium tetrachloride; In dichloromethane; at -78 ℃; for 1.5h; Inert atmosphere;

With triethylsilane; In dichloromethane; acetonitrile; at 20 ℃; for 3h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol203093g