Ethyl 2-(N-Methoxy-N-MethylaMino)-2-oxoacetate

Base Information

• Chemical Name: Ethyl 2-(N-Methoxy-N-MethylaMino)-2-oxoacetate
• CAS No.: 139507-52-1
• Molecular Formula: C6H11NO4
• Molecular Weight: 161.158
• Hs Code.: 2922509090
• Mol file: 139507-52-1.mol

Synonyms:monoethoxyoxalic acid-N-methoxy-N-methylamide;ethyl 1-(N-methoxy-N-methyl-amino)-1-oxo-acetate;ethyl 2-(methoxy(methyl)amino)-2-oxoacetate;Ethyl [methoxy(methyl)amino]oxoacetate;1-Cbz-3-isopropylpiperidine-3-carboxylic Acid;

Chemical Property of Ethyl 2-(N-Methoxy-N-MethylaMino)-2-oxoacetate

Chemical Property:

• PSA: 66.84000
• LogP: 3.08390
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-(n-methoxy-n-methylamino)-2-oxoacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-(N-Methoxy-N-MethylaMino)-2-oxoacetate

There total 1 articles about Ethyl 2-(N-Methoxy-N-MethylaMino)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + Ethyl oxalyl chloride (4755-77-5) → monoethoxyoxalic acid N-methoxy-N-methylamide (139507-52-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 ℃; for 14h;

DOI:10.1002/asia.201801035

Reference yield: 92.0%

Benzyl propargyl ether (4039-82-1) + monoethoxyoxalic acid N-methoxy-N-methylamide (139507-52-1) → ethyl 5-(benzyloxy)-2-oxopent-3-ynoate

Guidance literature:

Benzyl propargyl ether; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h;

monoethoxyoxalic acid N-methoxy-N-methylamide; In diethyl ether; hexane; for 2h;

DOI:10.1002/asia.201801016

Reference yield: 92.0%

(4-Nitrophenyl)acetylene (937-31-5) + monoethoxyoxalic acid N-methoxy-N-methylamide (139507-52-1) → ethyl 4-(4-nitrophenyl)-2-oxobut-3-ynoate (1085251-02-0)

Guidance literature:

(4-Nitrophenyl)acetylene; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

monoethoxyoxalic acid N-methoxy-N-methylamide; In diethyl ether; hexane; at -78 ℃; for 4h; Inert atmosphere;

DOI:10.1002/asia.201801035

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

Ethyl oxalyl chloride

Downstream raw materials:

ethyl 2-oxohexanoate

N-Methoxy-N-methyl-α-oxohexaneamide

ethyl (2-methoxyphenyl)(oxo)acetate

ethyl 2-oxo-4-phenylbut-3-ynoate