1-Benzylamino-2-benzyloxyethane

Base Information

• Chemical Name: 1-Benzylamino-2-benzyloxyethane
• CAS No.: 38336-06-0
• Molecular Formula: C16H19NO
• Molecular Weight: 241.333
• DSSTox Substance ID: DTXSID001256472
• Nikkaji Number: J637.540E
• Mol file: 38336-06-0.mol

Synonyms:1-Benzylamino-2-benzyloxyethane;N,O-dibenzylethanolamine;2-(benzyloxy)ethylbenzylamine;SCHEMBL176947;N-Benzyl-2-benzyloxyethylamine;N-(2(benzyloxy)ethyl)benzylamine;N-Benzyl-2-(benzyloxy)ethanamine;DTXSID001256472;N-(2-(benzyloxy)ethyl)benzylamine;N-Benzyl-2-(benzyloxy)ethanamine #;N-Benzyl-2-(benzyloxy)ethane amine;AKOS011858516;N-[2-(Phenylmethoxy)ethyl]benzenemethanamine;38336-06-0

Chemical Property of 1-Benzylamino-2-benzyloxyethane

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 7
• Exact Mass: 241.146664230
• Heavy Atom Count: 18
• Complexity: 195

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CNCCOCC2=CC=CC=C2

Technology Process of 1-Benzylamino-2-benzyloxyethane

There total 11 articles about 1-Benzylamino-2-benzyloxyethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N,N-dibenzyl-2-(benzyloxy)-1-ethanamine (91988-73-7) → N-benzyl-2-(benzyloxy)ethan-1-amine (38336-06-0)

Guidance literature:

With ammonium cerium(IV) nitrate; water; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1039/b000071j

Reference yield:

benzyl bromide (100-39-0) + ethanolamine (141-43-5) → O-benzylethanolamine (38336-04-8) + N-benzyl-2-(benzyloxy)ethan-1-amine (38336-06-0) + N-Benzylethanolamine (104-63-2)

Guidance literature:

With sodium hydride; tetra(tert-butyl)-ammonium fluoride; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) THF, reflux, 0.5 h, 2.) THF, 20 deg C, 3 h;

DOI:10.1080/00397919508013428

Reference yield:

benzyl chloride (100-44-7) + ethanolamine (141-43-5) → O-benzylethanolamine (38336-04-8) + N-benzyl-2-(benzyloxy)ethan-1-amine (38336-06-0) + N-Benzylethanolamine (104-63-2)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, reflux, 0.5 h, 2.) TH , reflux, 2 h;

DOI:10.1080/00397919508013428

upstream raw materials:

ethanolamine

benzyl chloride

N-Benzylethanolamine

benzyl bromide

Downstream raw materials:

(S)-2-[3-Benzyl-3-(2-benzyloxy-ethyl)-ureido]-3-phenyl-propionic acid

2-[3-benzyl-3-(2-benzyloxy-ethyl)-ureido]-N-methoxy-N-methyl-3-phenyl-propionamide

(R)-2-(N-benzyl-N-(2-(benzyloxy)ethyl)amino)-1-(3-nitrophenyl)ethan-1-ol

(R)-N-benzyl-N-(2-(benzyloxy)ethyl)-2-(3-nitrophenyl)-2-((triethylsilyl)oxy)ethan-1-amine