Benzoic acid, 2,4-dihydroxy-6-pentyl-, ethyl ester

Base Information

• Chemical Name: Benzoic acid, 2,4-dihydroxy-6-pentyl-, ethyl ester
• CAS No.: 38862-65-6
• Molecular Formula: C14H20O4
• Molecular Weight: 252.31
• Hs Code.: 2918199090
• Mol file: 38862-65-6.mol

Synonyms:2,4-Dihydroxy-6-pentyl-benzoesaeure-aethylester;BENZOIC ACID,2,4-DIHYDROXY-6-PENTYL-,ETHYL ESTER;2,4-dihydroxy-6-pentyl-benzoic acid ethyl ester;

Chemical Property of Benzoic acid, 2,4-dihydroxy-6-pentyl-, ethyl ester

Chemical Property:

• Melting Point: 69 °C
• Boiling Point: 420.4±30.0 °C(Predicted)
• PKA: 8.30±0.23(Predicted)
• PSA: 66.76000
• Density: 1.131±0.06 g/cm3(Predicted)
• LogP: 3.00720
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

Ethyl2,4-dihydroxy-6-pentylbenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Ethyl Olivetolate is used for preparation of crystalline Cannabidiol for pharmaceutical formulations.

Technology Process of Benzoic acid, 2,4-dihydroxy-6-pentyl-, ethyl ester

There total 7 articles about Benzoic acid, 2,4-dihydroxy-6-pentyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3,5-dibromo-2,4-dihydroxy-6-n-pentylbenzoic acid ethyl ester (58497-40-8) → 2,4-dihydroxy-6-n-pentylbenzoic acid ethyl ester (38862-65-6)

Guidance literature:

With hydrogen; sodium acetate; palladium on activated charcoal; In acetic acid; Ambient temperature;

DOI:10.1248/cpb.31.407

Reference yield: 72.0%

C14H18Br2O2 → 2,4-dihydroxy-6-n-pentylbenzoic acid ethyl ester (38862-65-6)

Guidance literature:

With water; sodium citrate; 5% palladium over charcoal; In ethanol; at 60 ℃; for 6h;

Reference yield:

C14H18O4(2-)*Na(1+) → 2,4-dihydroxy-6-n-pentylbenzoic acid ethyl ester (38862-65-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / acetic acid / 7 h / 20 - 55 °C

2: water; sodium citrate / 5% palladium over charcoal / ethanol / 6 h / 60 °C

With water; sodium acetate; sodium citrate; 5% palladium over charcoal; In ethanol; acetic acid;

upstream raw materials:

ethanol

anziaic acid

3,5-dibromo-2,4-dihydroxy-6-n-pentylbenzoic acid ethyl ester

4-methyleneoxetan-2-one

Downstream raw materials:

C_5:0-anacardic acid

ethyl 2-hydroxy-6-pentylbenzoate

(6aS,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol

cannabidiol

Refernces

• 1、 -. "Process for production of delta-9- tetrahydrocannabinol". . . Retrieved 2010/11/26.