Ethyl 2-(picolinamido)acetate

Base Information

• Chemical Name: Ethyl 2-(picolinamido)acetate
• CAS No.: 39484-31-6
• Molecular Formula: C10H12N2O3
• Molecular Weight: 208.217
• DSSTox Substance ID: DTXSID80423672
• Nikkaji Number: J2.152.064K

Synonyms:Ethyl 2-(picolinamido)acetate;39484-31-6;ethyl 2-(pyridine-2-carbonylamino)acetate;Glycine, N-(2-pyridinylcarbonyl)-, ethyl ester;[(Pyridine-2-carbonyl)amino]acetic acid ethyl ester;Ethyl2-(picolinamido)acetate;ethyl picolinoylglycinate;[(Pyridine-2-carbonyl)-amino]-acetic acid, ethyl ester;DTXSID80423672;NBVRSKVJAGQDEP-UHFFFAOYSA-N;N-(2-Oxo-2-ethoxyethyl)pyridine-2-carboxamide

Chemical Property of Ethyl 2-(picolinamido)acetate

Chemical Property:

• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 208.08479225
• Heavy Atom Count: 15
• Complexity: 231

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CNC(=O)C1=CC=CC=N1

Technology Process of Ethyl 2-(picolinamido)acetate

There total 1 articles about Ethyl 2-(picolinamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

pyridine (110-86-1) + Ethyl isocyanoacetate (2999-46-4) → 2-chloropyridine (109-09-1) + N-(2-pyridinecarbonyl)-glycine ethyl ester (39484-31-6) + (2-oxo-2-pyridin-2-yl-acetylamino)-acetic acid ethyl ester

Guidance literature:

pyridine; With fluorine; In dichloromethane; at -78 - -50 ℃;

Ethyl isocyanoacetate; In dichloromethane; at -50 - 0 ℃; for 4h;

DOI:10.1016/j.tetlet.2005.02.010

Reference yield: 88.0%

N-(2-pyridinecarbonyl)-glycine ethyl ester (39484-31-6) + toluene (108-88-3,15644-74-3,16713-13-6) → N-(2-pyridinecarbonyl)-phenylalanine ethyl ester

Guidance literature:

With bis(acetylacetonate)nickel(II); di-tert-butyl peroxide; at 20 - 140 ℃; for 18h; Inert atmosphere;

Reference yield: 80.0%

N-(2-pyridinecarbonyl)-glycine ethyl ester (39484-31-6) + m-xylene (108-38-3,104809-90-7) → N-(2-pyridinecarboxamido)-β-(3-methylphenyl)alanine ethyl ester

Guidance literature:

With bis(acetylacetonate)nickel(II); di-tert-butyl peroxide; at 20 - 150 ℃; for 18h; Inert atmosphere;

upstream raw materials:

pyridine

Ethyl isocyanoacetate

Downstream raw materials:

ethyl imidazo<1,5-a>pyridine-3-carboxylate

ethyl 3-phenyl-2-(N-tert-butoxycarbonyl)aminopropanoate

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