(E)-1-(4-Methylphenyl)-N-[(Z)-(4-methylphenyl)methylideneamino]methanimine

Base Information

• Chemical Name: (E)-1-(4-Methylphenyl)-N-[(Z)-(4-methylphenyl)methylideneamino]methanimine
• CAS No.: 4702-76-5
• Molecular Formula: C₁₆H₁₆N₂
• Molecular Weight: 236.316
• European Community (EC) Number: 653-704-0
• NSC Number: 122501
• Mol file: 4702-76-5.mol

Synonyms:4702-76-5;(E)-1-(4-Methylphenyl)-N-[(Z)-(4-methylphenyl)methylideneamino]methanimine;NSC122501;NSC-122501

Chemical Property of (E)-1-(4-Methylphenyl)-N-[(Z)-(4-methylphenyl)methylideneamino]methanimine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 346.1°Cat760mmHg
• Flash Point: 155.3°C
• Density: 0.98g/cm³
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 236.131348519
• Heavy Atom Count: 18
• Complexity: 250

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C=NN=CC2=CC=C(C=C2)C
• Isomeric SMILES: CC1=CC=C(C=C1)/C=N/N=C\C2=CC=C(C=C2)C

Technology Process of (E)-1-(4-Methylphenyl)-N-[(Z)-(4-methylphenyl)methylideneamino]methanimine

There total 36 articles about (E)-1-(4-Methylphenyl)-N-[(Z)-(4-methylphenyl)methylideneamino]methanimine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-methyl-benzaldehyde (104-87-0) → 4,4'-dimethylbenzaldazine (4702-76-5,139030-29-8)

Guidance literature:

With bismuth(III) chloride; hydrazine; In water; at 20 ℃; for 0.0166667h; Sonication; Green chemistry;

DOI:10.1016/j.ultsonch.2013.12.011

Reference yield: 87.0%

carbon tetrabromide (558-13-4) + 4-methylbenzaldehyde hydrazone (52693-87-5) → 1-(2,2-dibromovinyl)-4-methylbenzene (60512-56-3) + 4,4'-dimethylbenzaldazine (4702-76-5,139030-29-8)

Guidance literature:

With copper(I) chloride; ammonium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 4h;

DOI:10.1055/s-2001-18055

Reference yield: 85.0%

3-methyl-4,5-dihydro-6-oxopyridazine (5157-08-4) + 4-methyl-benzaldehyde (104-87-0) → N,N'-Bis-[1-p-tolyl-meth-(E)-ylidene]-hydrazine (4702-76-5,139030-29-8) + 6-methyl-4-(4-methylbenzyl)pyridazine-3(2H)-one (74819-18-4)

Guidance literature:

With sodium ethanolate; In ethanol; Ambient temperature;

upstream raw materials:

4-methyl-benzaldehyde

para-methylbenzonitrile

ethanol

p-tolyldiazomethane

Downstream raw materials:

[amino-(4-methylphenyl)methyl]phosphonic acid

3,3-dimethyl-7,11-cis-di(p-methylphenyl)-2,4-dioxaspiro[5.5]undecane-1,5,9-trione

3-(4-methyl-benzylideneamino)-2-p-tolyl-[1,3]thiazinan-4-one

4-methyl-benzaldehyde [4-oxo-5-(4-methyl-benzylidene)-thiazolidin-2-ylidene]-hydrazone

Refernces

• 1、 -. "Dihydrazone compound high in affinity with Abeta protein and Tau protein, derivative thereof, and applications of dihydrazone compound and derivative". Paragraph 0029-0031; 0044-0046. . Retrieved 2019/05/15.
• 2、 Kallitsakis, Michael G.,Tancini, Peter D.,Dixit, Mudit,Mpourmpakis, Giannis,Lykakis, Ioannis N.. "Mechanistic Studies on the Michael Addition of Amines and Hydrazines to Nitrostyrenes: Nitroalkane Elimination via a Retro-aza-Henry-Type Process". . p. 1176 - 1184. Retrieved 2018/02/09.