2-(Diethylamino)-N-(4-hydroxy-2,6-dimethylphenyl)acetamide

Base Information

Chemical Name:2-(Diethylamino)-N-(4-hydroxy-2,6-dimethylphenyl)acetamide
CAS No.:39942-41-1
Molecular Formula:C14H22N2O2
Molecular Weight:250.33700
Hs Code.:
DSSTox Substance ID:DTXSID20552834
Nikkaji Number:J2.859.411I
Mol file:39942-41-1.mol

Synonyms:4-hydroxylidocaine

Suppliers and Price of 2-(Diethylamino)-N-(4-hydroxy-2,6-dimethylphenyl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Hydroxylidocaine
1mg
$ 175.00

TRC
4-Hydroxylidocaine
10mg
$ 1355.00

Medical Isotopes, Inc.
4-Hydroxylidocaine
1 mg
$ 390.00

Total 4 raw suppliers

Chemical Property of 2-(Diethylamino)-N-(4-hydroxy-2,6-dimethylphenyl)acetamide

Chemical Property:

Melting Point:178-180°C
PSA：56.06000
LogP:2.93880
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:250.168127949
Heavy Atom Count:18
Complexity:255

Purity/Quality:

99% ^*data from raw suppliers

4-Hydroxylidocaine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)CC(=O)NC1=C(C=C(C=C1C)O)C
Uses 4-Hydroxylidocaine, is a metabolite of Lidocaine (L397800), a common local anesthetic and antiarrhythmic drug.

Technology Process of 2-(Diethylamino)-N-(4-hydroxy-2,6-dimethylphenyl)acetamide

There total 5 articles about 2-(Diethylamino)-N-(4-hydroxy-2,6-dimethylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 39942-41-1
4-hydroxylidocaine

: 34604-55-2
3-Hydroxylidocaine

Guidance literature:: With water; trifluoroacetic acid; In acetonitrile; for 0.5h; pH=5; Reagent/catalyst; Electrochemical reaction; Inert atmosphere;
DOI:10.1016/j.electacta.2016.12.089

Reference yield:

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 2903-45-9
lidocaine N-oxide

: 39942-41-1
4-hydroxylidocaine

: 34604-55-2
3-Hydroxylidocaine

: 7728-40-7
N-(2,6-dimethylphenyl)-2-ethylaminoacetamide

: 64585-18-8
2-diethylamino-2'-hydroxymethyl-6'-methyl acetanilide

Guidance literature:: With tetrabutylammonium perchlorate; In water; acetonitrile; at 20 ℃; for 0.5h; Electrochemical reaction;
DOI:10.1021/ac200897p

Reference yield:

: 19628-76-3
3,5-dimethyl-4-nitrosophenol

: 39942-41-1
4-hydroxylidocaine

Guidance literature:: Multi-step reaction with 3 steps

1: aqueous NH₃; H₂S

2: aqueous HCl; sodium acetate

With hydrogenchloride; ammonium hydroxide; hydrogen sulfide; sodium acetate;