4-(4-Chlorophenyl)sulfonyl-1-[2-(2,4-difluorophenyl)ethyl]piperidine

Base Information

Chemical Name:4-(4-Chlorophenyl)sulfonyl-1-[2-(2,4-difluorophenyl)ethyl]piperidine
CAS No.:400729-10-4
Molecular Formula:C₁₉H₂₀ClF₂NO₂S
Molecular Weight:399.889
Hs Code.:
ChEMBL ID:CHEMBL149429
DSSTox Substance ID:DTXSID80473910
Nikkaji Number:J1.718.903D
Pharos Ligand ID:L8M6LP9Q64G4

Synonyms:CHEMBL149429;4-(4-chlorophenyl)sulfonyl-1-[2-(2,4-difluorophenyl)ethyl]piperidine;400729-10-4;DTXSID80473910;BDBM50108689;4-(4-Chloro-benzenesulfonyl)-1-[2-(2,4-difluoro-phenyl)-ethyl]-piperidine;4-(4-Chlorophenylsulfonyl)-1-(2-(2,4-difluorophenyl)-ethyl)piperidine

Suppliers and Price of 4-(4-Chlorophenyl)sulfonyl-1-[2-(2,4-difluorophenyl)ethyl]piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-(4-Chlorophenyl)sulfonyl-1-[2-(2,4-difluorophenyl)ethyl]piperidine

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:399.0871341
Heavy Atom Count:26
Complexity:540

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1S(=O)(=O)C2=CC=C(C=C2)Cl)CCC3=C(C=C(C=C3)F)F

Technology Process of 4-(4-Chlorophenyl)sulfonyl-1-[2-(2,4-difluorophenyl)ethyl]piperidine

There total 5 articles about 4-(4-Chlorophenyl)sulfonyl-1-[2-(2,4-difluorophenyl)ethyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1142-19-4
4,4'-dichlorodiphenyl disulfide

: 400729-10-4
4-(4-chloro-benzenesulfonyl)-1-[2-(2,4-difluoro-phenyl)-ethyl]-piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: tri(n-butyl)phosphine / tetrahydrofuran / 48 h / Heating

2: oxone; Al₂O₃ / CHCl₃; H₂O / 18 h / Heating

3: 5 N aq. HCl / methanol / 3 h / Heating

4: K₂CO₃; NaI / acetonitrile / 18 h / Heating

With hydrogenchloride; aluminum oxide; Oxone; tributylphosphine; potassium carbonate; sodium iodide; In tetrahydrofuran; methanol; chloroform; water; acetonitrile;
DOI:10.1021/jm011030v

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 400729-10-4
4-(4-chloro-benzenesulfonyl)-1-[2-(2,4-difluoro-phenyl)-ethyl]-piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: tri(n-butyl)phosphine / tetrahydrofuran / 48 h / Heating

2: oxone; Al₂O₃ / CHCl₃; H₂O / 18 h / Heating

3: 5 N aq. HCl / methanol / 3 h / Heating

4: K₂CO₃; NaI / acetonitrile / 18 h / Heating

With hydrogenchloride; aluminum oxide; Oxone; tributylphosphine; potassium carbonate; sodium iodide; In tetrahydrofuran; methanol; chloroform; water; acetonitrile;
DOI:10.1021/jm011030v

Reference yield:

: 333954-87-3
tert-butyl 4-[(4-chlorophenyl)thio] piperidine-1-carboxylate

: 400729-10-4
4-(4-chloro-benzenesulfonyl)-1-[2-(2,4-difluoro-phenyl)-ethyl]-piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: oxone; Al₂O₃ / CHCl₃; H₂O / 18 h / Heating

2: 5 N aq. HCl / methanol / 3 h / Heating

3: K₂CO₃; NaI / acetonitrile / 18 h / Heating

With hydrogenchloride; aluminum oxide; Oxone; potassium carbonate; sodium iodide; In methanol; chloroform; water; acetonitrile;
DOI:10.1021/jm011030v