333954-87-3

Usage

Molecular structure

1-Piperidinecarboxylic acid, 4-[(4-chlorophenyl)thio]features a piperidine ring structure with a thiol group attached to a 4-chlorophenyl group, and a 1,1-dimethylethyl ester functional group.

Classification

It is a tertiary amine and thiol-based compound.

Usage

The compound is commonly used in organic synthesis and pharmaceutical research as a precursor to various pharmaceuticals and agrochemicals due to its versatile reactivity and potential biological activity.

Stability

The 1,1-dimethylethyl ester derivative is known for its stability and ease of handling, making it a valuable starting material for the synthesis of complex organic molecules.

Potential therapeutic applications

The compound may have potential therapeutic applications due to its pharmacological properties, and it is the subject of ongoing research in the pharmaceutical industry.

Upstream product

• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 106-54-7 p-Chlorothiophenol 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 1872262-73-1 1-(tert-butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate 
• 180695-79-8 tert-butyl 4-bromo-1-piperidinecarboxylate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 

Downstream Products

• 101768-63-2 4-((4-chlorophenyl)thio)piperidine 
• 442199-04-4 5-Chloro-N-[(1S)-2-[(2-{4-[(4-chlorophenyl)thio]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide 
• 442199-03-3 (2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(4-chlorophenyl)thio]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide 
• 400729-10-4 4-(4-chloro-benzenesulfonyl)-1-[2-(2,4-difluoro-phenyl)-ethyl]-piperidine 
• 345660-48-2 4-[(4-chlorophenyl)sulfonyl]piperidine 
• 333954-88-4 4-(4-Chloro-benzenesulfonyl)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Visible Light-Driven Decarboxylative Alkylation of Aldehydes via Electron Donor–Acceptor Complexes of Active Esters

There are some synthesis methods from widely available aldehydes to the corresponding ketones, however, they involved in multistep reactions with Grignard’s reagents or transition metal catalysts. In this paper, we have developed photocatalyst-free and visible light-driven decarboxylative alkylation of pyridinaldehydes. The photochemical reactions are initiated via photoinduced single electron transfer from triethylamine to N-hydroxyphthalimide esters in electron donor–acceptor complexes. This photochemical method can achieve to translate 15 pyridinaldehydes and 11 2-quinolinaldehydes to the corresponding ketones. Furthermore, this strategy can also achieve two other transformations, disulfanes to aryl sulfides and a styrene sulfone to the alkyl-substituted alkene.

Visible-Light-Mediated Alkylation of Thiophenols via Electron Donor-Acceptor Complexes Formed between Two Reactants

A metal-free, photocatalyst-free, photochemical system was developed for the direct alkylation of thiophenols via electron donor-acceptor (EDA) complexes (KEDA = 145 M-1) between two reactants, N-hydroxyphthalimide esters as acceptors and thiophenol anions as donors, in the presence of a tertiary amine. The EDA complexes in the reaction system have a broad range of visible-light absorption (400-650 nm) and can trigger the reaction effectively under sunlight.

NOVEL COMPOUNDS USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS

The present invention relates to novel morpholine, oxazapane and piperidine derivatives that act as ligands for CC chemokine receptors, such as CCR1. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

Peptide compounds

The present invention relates to a compound of the formula (I)wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts thereof. The compound (1) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases in human being and animals.

4-(Phenylsulfonyl)piperidines: Novel, selective, and bioavailable 5-HT2A receptor antagonists

On the basis of a spirocyclic ether screening lead, a series of acyclic sulfones have been identifed as high-affinity, selective 5-HT2A receptor antagonists. Bioavailability lacking in the parent, 1-(2-(2,4-difluorophenyl)ethyl)-4-(phenylsulfon