Carbamic acid, [2-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-cyclohexyl-4-[[(1,1-dimethyleth yl)amino]carbonyl]-1-piperidinyl]-2-oxoethyl]amino]carbonyl]-2,3-dihydro -1H-inden-1-yl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [2-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-cyclohexyl-4-[[(1,1-dimethyleth yl)amino]carbonyl]-1-piperidinyl]-2-oxoethyl]amino]carbonyl]-2,3-dihydro -1H-inden-1-yl]-, 1,1-dimethylethyl ester
CAS No.:401843-96-7
Molecular Formula:C40H55ClN4O5
Molecular Weight:707.353
Hs Code.:

Carbamic acid,
[2-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-cyclohexyl-4-[[(1,1-dimethyleth
yl)amino]carbonyl]-1-piperidinyl]-2-oxoethyl]amino]carbonyl]-2,3-dihydro
-1H-inden-1-yl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [2-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-cyclohexyl-4-[[(1,1-dimethyleth yl)amino]carbonyl]-1-piperidinyl]-2-oxoethyl]amino]carbonyl]-2,3-dihydro -1H-inden-1-yl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [2-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-cyclohexyl-4-[[(1,1-dimethyleth yl)amino]carbonyl]-1-piperidinyl]-2-oxoethyl]amino]carbonyl]-2,3-dihydro -1H-inden-1-yl]-, 1,1-dimethylethyl ester

There total 8 articles about Carbamic acid, [2-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-cyclohexyl-4-[[(1,1-dimethyleth yl)amino]carbonyl]-1-piperidinyl]-2-oxoethyl]amino]carbonyl]-2,3-dihydro -1H-inden-1-yl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57292-44-1
N-Boc-D-(4-Cl)Phe-OH

: 401843-96-7
{2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-chloro-benzyl)-2-oxo-ethylcarbamoyl]-indan-1-yl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: EDC; HOBT; NMM / CH₂Cl₂

2: HCl / CH₂Cl₂; dioxane

3: EDC; HOBT; NMM / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2005.05.012

Reference yield:

: 363192-59-0
(2R)-2-(BOC-amino)-N-[4-cyclohexyl-4-(t-butylcarbamoyl)piperidin-1-yl]-3-(4-chlorophenyl)propionamide

: 401843-96-7
{2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-chloro-benzyl)-2-oxo-ethylcarbamoyl]-indan-1-yl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / CH₂Cl₂; dioxane

2: EDC; HOBT; NMM / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2005.05.012

Reference yield:

: 40073-45-8
6,7-Benzo-2-azabicyclo<3.2.0>heptan-3-on

: 401843-96-7
{2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-chloro-benzyl)-2-oxo-ethylcarbamoyl]-indan-1-yl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DMAP; Et₃N / CH₂Cl₂

2: aq. LiOH / tetrahydrofuran

3: EDC; HOBT; NMM / CH₂Cl₂

With 4-methyl-morpholine; dmap; lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.05.012