6-(2-Chlorophenyl)-2-methylthio-pyrido[2,3-d]pyrimidin-7-ol

Base Information

Chemical Name:6-(2-Chlorophenyl)-2-methylthio-pyrido[2,3-d]pyrimidin-7-ol
CAS No.:402740-45-8
Molecular Formula:C14H10ClN3OS
Molecular Weight:303.772
Hs Code.:
DSSTox Substance ID:DTXSID30476512
Wikidata:Q82307950
Mol file:402740-45-8.mol

Synonyms:6-(2-chlorophenyl)-2-methylthio-pyrido[2,3-d]pyrimidin-7-ol;6-(2-chlorophenyl)-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one;402740-45-8;SCHEMBL6216934;SCHEMBL14370847;DTXSID30476512;YDZNALQKYIQPEG-UHFFFAOYSA-N;6-(2-chlorophenyl)-2-(methylsulfanyl)-7H,8H-pyrido[2,3-d]pyrimidin-7-one

Suppliers and Price of 6-(2-Chlorophenyl)-2-methylthio-pyrido[2,3-d]pyrimidin-7-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(2-Chlorophenyl)-2-methylthio-pyrido[2,3-d]pyrimidin-7-ol

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:303.0233108
Heavy Atom Count:20
Complexity:417

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CSC1=NC=C2C=C(C(=O)NC2=N1)C3=CC=CC=C3Cl

Technology Process of 6-(2-Chlorophenyl)-2-methylthio-pyrido[2,3-d]pyrimidin-7-ol

There total 4 articles about 6-(2-Chlorophenyl)-2-methylthio-pyrido[2,3-d]pyrimidin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 770-31-0
4-amino-2-(methylthio)pyrimidine-5-carbaldehyde

: 57486-68-7
methyl (2-chlorophenyl)acetate

: 402740-45-8
6-(2-chlorophenyl)-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 110 ℃;

Reference yield:

: 588-36-3
(4-amino-2-(methylthio)pyrimidin-5-yl)methanol

: 402740-45-8
6-(2-chlorophenyl)-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / chloroform / 20 °C

2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 110 °C

With manganese(IV) oxide; potassium carbonate; In 1-methyl-pyrrolidin-2-one; chloroform;

Reference yield:

: 5909-24-0
4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

: 402740-45-8
6-(2-chlorophenyl)-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; ammonium hydroxide / tetrahydrofuran / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C

3: manganese(IV) oxide / chloroform / 20 °C

4: potassium carbonate / 1-methyl-pyrrolidin-2-one / 110 °C

With manganese(IV) oxide; ammonium hydroxide; lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; chloroform;