Benzamide, 2-bromo-N-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]-

Base Information

Chemical Name:Benzamide, 2-bromo-N-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]-
CAS No.:402755-63-9
Molecular Formula:C13H18BrNO2
Molecular Weight:300.195
Hs Code.:
Mol file:402755-63-9.mol

Synonyms:Benzamide, 2-bromo-N-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]-

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Chemical Property of Benzamide, 2-bromo-N-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]-

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Technology Process of Benzamide, 2-bromo-N-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]-

There total 3 articles about Benzamide, 2-bromo-N-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

: 112245-13-3
(S)-tert-leucinol

: 7154-66-7
2-bromobenzoic acid chloride

: 402755-63-9
2-bromo-N-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]-benzamide

Guidance literature:: With sodium carbonate; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ja044812x

Reference yield:

: 88-65-3
2-bromobenzoic-acid

: 402755-63-9
2-bromo-N-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / 80 °C

2: triethylamine / 0 - 20 °C

With thionyl chloride; triethylamine;
DOI:10.1016/j.tet.2012.02.078

Reference yield:

: 20859-02-3
L-tert-Leucine

: 402755-63-9
2-bromo-N-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; iodine / tetrahydrofuran / 18.5 h / 4 - 80 °C / Inert atmosphere

2: sodium carbonate / dichloromethane; water / 10.25 h / 20 °C

With sodium tetrahydroborate; iodine; sodium carbonate; In tetrahydrofuran; dichloromethane; water;