methyl (2S,4R)-4-hydroxy-1-[(1S)-1-phenylethyl]piperidine-2-carboxylate

Base Information

Chemical Name:methyl (2S,4R)-4-hydroxy-1-[(1S)-1-phenylethyl]piperidine-2-carboxylate
CAS No.:403503-26-4
Molecular Formula:C15H21NO3
Molecular Weight:263.337
Hs Code.:
DSSTox Substance ID:DTXSID20573468
Nikkaji Number:J1.614.949G
Wikidata:Q82462200

Synonyms:403503-26-4;SCHEMBL16282514;DTXSID20573468;methyl (2S,4R)-4-hydroxy-1-[(1S)-1-phenylethyl]piperidine-2-carboxylate

Suppliers and Price of methyl (2S,4R)-4-hydroxy-1-[(1S)-1-phenylethyl]piperidine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of methyl (2S,4R)-4-hydroxy-1-[(1S)-1-phenylethyl]piperidine-2-carboxylate

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:263.15214353
Heavy Atom Count:19
Complexity:302

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=CC=C1)N2CCC(CC2C(=O)OC)O
Isomeric SMILES:C[C@@H](C1=CC=CC=C1)N2CC[C@H](C[C@H]2C(=O)OC)O

Technology Process of methyl (2S,4R)-4-hydroxy-1-[(1S)-1-phenylethyl]piperidine-2-carboxylate

There total 1 articles about methyl (2S,4R)-4-hydroxy-1-[(1S)-1-phenylethyl]piperidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 298-12-4
Glyoxilic acid

: 114963-47-2
N-(3-butenyl)-N-[(S)-1-phenylethyl]amine

: 1103929-22-1
(2R,4S)-4-Hydroxy-1-((S)-1-phenyl-ethyl)-piperidine-2-carboxylic acid methyl ester

: 403503-26-4,1103929-22-1
(2S,4R)-4-Hydroxy-1-((S)-1-phenyl-ethyl)-piperidine-2-carboxylic acid methyl ester

Guidance literature:: Glyoxilic acid; N-(3-butenyl)-N-[(S)-1-phenylethyl]amine; In water; acetonitrile; at 20 ℃;

methanol; With ammonia;
DOI:10.1016/S0040-4039(01)01660-4

Reference yield: 84.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 403503-26-4,1103929-22-1
(2S,4R)-4-Hydroxy-1-((S)-1-phenyl-ethyl)-piperidine-2-carboxylic acid methyl ester

: 403503-37-7,1357348-22-1
(2S,4R)-1-benzyl 2-methyl 4-hydroxypiperidine-1,2-dicarboxylate

Guidance literature:: (2S,4R)-4-Hydroxy-1-((S)-1-phenyl-ethyl)-piperidine-2-carboxylic acid methyl ester; With hydrogenchloride; hydrogen; palladium dihydroxide; In methanol;

benzyl chloroformate; With sodium carbonate; at 0 ℃;
DOI:10.1016/S0040-4039(01)01660-4

Reference yield:

: 403503-26-4,1103929-22-1
(2S,4R)-4-Hydroxy-1-((S)-1-phenyl-ethyl)-piperidine-2-carboxylic acid methyl ester

: 403503-67-3
(S)-4,4-Difluoro-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂; HCl / Pd(OH)2/C / methanol

1.2: 84 percent / Na₂CO₃ / 0 °C

2.1: 85 percent / DMSO; (COCl)2 / triethylamine

3.1: 39 percent / DAST / tetrahydrofuran

With hydrogenchloride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; 4,4'-diaminostilbene-2,2'-disulfonic acid; palladium dihydroxide; In tetrahydrofuran; methanol; triethylamine; 2.1: Swern oxidation;
DOI:10.1016/S0040-4039(01)01660-4