1,2-Piperidinedicarboxylic acid, 4-(formyloxy)-, 2-methyl 1-(phenylmethyl) ester, (2S,4S)-

Base Information

Chemical Name:1,2-Piperidinedicarboxylic acid, 4-(formyloxy)-, 2-methyl 1-(phenylmethyl) ester, (2S,4S)-
CAS No.:403503-40-2
Molecular Formula:C16H19NO6
Molecular Weight:321.33
Hs Code.:

Synonyms:

Suppliers and Price of 1,2-Piperidinedicarboxylic acid, 4-(formyloxy)-, 2-methyl 1-(phenylmethyl) ester, (2S,4S)-

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Chemical Property of 1,2-Piperidinedicarboxylic acid, 4-(formyloxy)-, 2-methyl 1-(phenylmethyl) ester, (2S,4S)-

Chemical Property:

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Technology Process of 1,2-Piperidinedicarboxylic acid, 4-(formyloxy)-, 2-methyl 1-(phenylmethyl) ester, (2S,4S)-

There total 6 articles about 1,2-Piperidinedicarboxylic acid, 4-(formyloxy)-, 2-methyl 1-(phenylmethyl) ester, (2S,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85-44-9
phthalic anhydride

: 475504-28-0
4-formyloxy-(S)-pipecolic acid methyl ester

: C₁₆H₁₉NO₆

: C₂₃H₂₃NO₈

: 403503-40-2
(2S,4S)-4-Formyloxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: 4-formyloxy-(S)-pipecolic acid methyl ester; With tert-butyl methyl ether; lipase AY₃₀ (Candida rugosa, Amano); In aq. phosphate buffer; at 20 ℃; for 96h; pH=7; Resolution of racemate; Enzymatic reaction;

phthalic anhydride; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/op020017x

Reference yield:

: 64-18-6
formic acid

: 403503-37-7,1357348-22-1
(2S,4R)-1-benzyl 2-methyl 4-hydroxypiperidine-1,2-dicarboxylate

: 403503-40-2
(2S,4S)-4-Formyloxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; Multistep reaction; 1.) THF, 1 h, 2.) THF, RT, overnight;
DOI:10.1016/S0960-894X(98)00231-5

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 403503-40-2
(2S,4S)-4-Formyloxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: H₂; HCl / Pd(OH)2/C / methanol

1.2: 84 percent / Na₂CO₃ / 0 °C

2.1: DEAD; Ph₃P / tetrahydrofuran / 5 °C

With hydrogenchloride; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium dihydroxide; In tetrahydrofuran; methanol; 2.1: Mitsunobu inversion;
DOI:10.1016/S0040-4039(01)01660-4