2-(3-PYRIDYL)-1H-BENZIMIDAZOLE 97

Base Information

• Chemical Name: 2-(3-PYRIDYL)-1H-BENZIMIDAZOLE 97
• CAS No.: 1137-67-3
• Molecular Formula: C12H9N3
• Molecular Weight: 195.224
• Hs Code.: 2933990090
• Mol file: 1137-67-3.mol

Synonyms:Benzimidazole,2-(3-pyridyl)- (6CI,7CI,8CI);2-(3-Pyridinyl)-1H-benzimidazole;2-(3-Pyridyl)-1H-benzimidazole;2-(3-Pyridyl)benzimidazole;2-(3'-Pyridyl)-1H-benzimidazole;2-(3'-Pyridyl)benzimidazole;2-(Pyridin-3-yl)benzimidazole;G 514;NSC 62610;

Chemical Property of 2-(3-PYRIDYL)-1H-BENZIMIDAZOLE 97

Chemical Property:

• Vapor Pressure: 1.33E-07mmHg at 25°C
• Melting Point: 253-257 °C(lit.)
• Refractive Index: 1.699
• Boiling Point: 430.1 °C at 760 mmHg
• PKA: 10.89±0.10(Predicted)
• Flash Point: 207.7 °C
• PSA: 41.57000
• Density: 1.27g/cm³
• LogP: 2.62490
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-(3-Pyridyl)benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: 2-(3-pyridyl)-Benzimidazole is a synthetic intermediate useful for pharmaceutical synthesis.

Technology Process of 2-(3-PYRIDYL)-1H-BENZIMIDAZOLE 97

There total 31 articles about 2-(3-PYRIDYL)-1H-BENZIMIDAZOLE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-Aminomethylpyridine (3731-52-0) + 1,2-diamino-benzene (95-54-5) → 2-(3-pyridyl)-1H-benzimidazole (1137-67-3)

Guidance literature:

With Al cations incorporated into the Si framework; open air; In neat (no solvent); at 100 ℃; for 15h; Green chemistry;

DOI:10.1039/d1gc02627e

Reference yield: 95.0%

nicotinic acid (59-67-6) + 1,2-diamino-benzene (95-54-5) → 2-(3-pyridyl)-1H-benzimidazole (1137-67-3)

Guidance literature:

With PPE; at 120 ℃; for 1h;

DOI:10.1248/cpb.30.2996

Reference yield: 95.0%

3-pyridinecarboxaldehyde (500-22-1) + 1,2-diamino-benzene (95-54-5) → 2-(3-pyridyl)-1H-benzimidazole (1137-67-3)

Guidance literature:

With zirconyl(IV) chloride; at 20 ℃; for 0.5h;

DOI:10.1134/S1070428006030201

upstream raw materials:

3-pyridinecarboxaldehyde

1,2-diamino-benzene

nicotinic acid

methyl-3-pyridylketone

Downstream raw materials:

2-(3'-pyridyl)-5-nitrobenzimidazole

1-{2-[4-(3-methoxyphenyl)piperazin-1-yl]ethyl}-2-pyridin-3-yl-1H-benzimidazole

1-[2-(4-phenylpiperazin-1-yl)ethyl]-2-pyridin-3-yl-1H-benzimidazole

1-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}-2-pyridin-3-yl-1H-benzimidazole