Benzene, 1,1'-[1,2-ethanediylbis(thio)]bis[4-fluoro-

Base Information

• Chemical Name: Benzene, 1,1'-[1,2-ethanediylbis(thio)]bis[4-fluoro-
• CAS No.: 405-95-8
• Molecular Formula: C14H12F2S2
• Molecular Weight: 282.378

Synonyms:

Chemical Property of Benzene, 1,1'-[1,2-ethanediylbis(thio)]bis[4-fluoro-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1,1'-[1,2-ethanediylbis(thio)]bis[4-fluoro-

There total 3 articles about Benzene, 1,1'-[1,2-ethanediylbis(thio)]bis[4-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-Fluorothiophenol (371-42-6) + 1,2-dichloro-ethane (107-06-2,52399-93-6) → 1,2-bis((4-fluorophenyl)thio)ethane (405-95-8)

Guidance literature:

With triethylamine; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1002/aoc.3273

Reference yield: 71.0%

4-Fluorothiophenol (371-42-6) + ethylene dibromide (106-93-4) → 1,2-bis((4-fluorophenyl)thio)ethane (405-95-8)

Guidance literature:

4-Fluorothiophenol; With potassium hydroxide; In methanol; at 0 ℃; for 0.166667h;

ethylene dibromide; In methanol; at 23 ℃; for 16h;

DOI:10.1002/chem.201301787

Reference yield:

ethylene dibromide (106-93-4) → 1,2-bis((4-fluorophenyl)thio)ethane (405-95-8)

Guidance literature:

With ethanol;

DOI:10.1002/jsfa.2740080106

upstream raw materials:

ethylene dibromide

4-Fluorothiophenol

1,2-dichloro-ethane

Downstream raw materials:

WI₂(CO)3(FC₆H₄SCH₂CH₂SC₆H₄F)

W(Br)2(CO)3(FC₆H₄S(CH₂)2SC₆H₄F)

Refernces

An efficient method for para-methoxybenzyl ether formation with lanthanum triflate

10.1016/S0040-4039(03)00282-X

The study presents an efficient method for the formation of para-methoxybenzyl (PMB) ethers using trichloroacetimidate of PMB alcohol and lanthanum triflate. The PMB group is widely used as a protecting group for alcohols due to its robustness under various chemical conditions. The authors explored different catalysts and solvents to find milder conditions for the protection of alcohols, especially those sensitive to basic conditions. They discovered that lanthanum triflate, among other metal triflates, is highly effective in catalyzing the formation of PMB ethers, allowing for high yields and short reaction times. The study tested various alcohols, including α-hydroxy ketones, glucose derivatives, and acid-sensitive epoxy alcohols, demonstrating the versatility and mildness of the method. The use of lanthanum triflate enabled the protection of even sensitive substrates under low-temperature conditions, highlighting its potential for practical applications in organic synthesis.

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