4-(4-Methoxyphenyl)-1-isopropyl-3,3-dichloroazetidine-2-one

Base Information

Chemical Name:4-(4-Methoxyphenyl)-1-isopropyl-3,3-dichloroazetidine-2-one
CAS No.:418765-66-9
Molecular Formula:C13H15Cl2NO2
Molecular Weight:288.174
Hs Code.:
DSSTox Substance ID:DTXSID70473848
Nikkaji Number:J1.758.501K

Synonyms:418765-66-9;4-(4-Methoxyphenyl)-1-isopropyl-3,3-dichloroazetidine-2-one;AGN-PC-00GVG4;DTXSID70473848

Suppliers and Price of 4-(4-Methoxyphenyl)-1-isopropyl-3,3-dichloroazetidine-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-Methoxyphenyl)-1-isopropyl-3,3-dichloroazetidine-2-one

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:287.0479841
Heavy Atom Count:18
Complexity:325

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)N1C(C(C1=O)(Cl)Cl)C2=CC=C(C=C2)OC

Technology Process of 4-(4-Methoxyphenyl)-1-isopropyl-3,3-dichloroazetidine-2-one

There total 2 articles about 4-(4-Methoxyphenyl)-1-isopropyl-3,3-dichloroazetidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 79-36-7
dichloroacethyl chloride

: 13033-52-8
isopropyl-[1-(4-methoxyphenyl)meth-(E)-ylidene]amine

: 418765-66-9
3,3-dichloro-1-isopropyl-4-(4-methoxyphenyl)-2-azetidinone

Guidance literature:: With triethylamine; In benzene; at 20 ℃; for 1h;
DOI:10.1021/jo010914j

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 418765-66-9
3,3-dichloro-1-isopropyl-4-(4-methoxyphenyl)-2-azetidinone

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium sulfate / CH₂Cl₂ / 1 h / Heating

2: 77 percent / triethylamine / benzene / 1 h / 20 °C

With magnesium sulfate; triethylamine; In dichloromethane; benzene;
DOI:10.1021/jo010914j