Arzoxifene

Base Information Edit

Chemical Name:Arzoxifene
CAS No.:182133-25-1
Molecular Formula:C28H29 N O4 S
Molecular Weight:475.609
Hs Code.:
UNII:E569WG6E60
DSSTox Substance ID:DTXSID10171255
Nikkaji Number:J1.017.482A
Wikipedia:Arzoxifene
Wikidata:Q4802769
NCI Thesaurus Code:C1805
Pharos Ligand ID:UPBRJ33V5RCN
Metabolomics Workbench ID:149702
ChEMBL ID:CHEMBL226267
Mol file:182133-25-1.mol

Synonyms:4'F-DMA;arzoxifene;LY 353381;LY-353381;LY353381;LY353381hydrochloride

Suppliers and Price of Arzoxifene

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Arzoxifene
0.5mg
$ 195.00

American Custom Chemicals Corporation
ARZOXIFENE 95.00%
5MG
$ 504.41

Total 7 raw suppliers

Chemical Property of Arzoxifene Edit

Chemical Property:

Vapor Pressure:7.85E-18mmHg at 25°C
Melting Point:174-176°
Boiling Point:656.4°Cat760mmHg
Flash Point:350.8°C
PSA：79.40000
Density:1.234g/cm³
LogP:6.87740
XLogP3:6.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:475.18172958
Heavy Atom Count:34
Complexity:601

Purity/Quality:

98%Min ^*data from raw suppliers

Arzoxifene ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=C(C3=C(S2)C=C(C=C3)O)OC4=CC=C(C=C4)OCCN5CCCCC5
Recent ClinicalTrials:LY353381 in Preventing Breast Cancer in Women With Hyperplasia
Recent EU Clinical Trials:“Comparación de la Eficacia y Seguridad de Arzoxifeno frente a Raloxifeno en mujeres posmenopáusicas con Osteoporosis”
Uses Arzoxifene is a selective estrogen receptor modulator. It is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol.
Clinical Use Arzoxifene is a third-generation SERM currently in Phase III clinical trials for the treatm ent of ER-positive recurrent/metastatic breast cancer. Similar to raloxifene, it is an ER antagonist in both breast and uterine tissues and an ER agonist on bone and the cardiovascular system. Arzoxifene is able to both preserve and build bone mineral density, which makes it a viable candidate for the treatment of osteoporosis. Ample evidence from early clinical trials indicates that arzoxifene also can be utilized as a chemopreventive agent against breast cancer.

Technology Process of Arzoxifene

There total 13 articles about Arzoxifene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 943439-50-7
4'-Bromo-4'-desmethoxyarzoxifene

: 124-41-4
sodium methylate

: 182133-25-1
arzoxifene

Guidance literature:: copper(l) iodide; ethyl acetate; In methanol; N,N-dimethyl-formamide; at 110 ℃; for 8h;
DOI:10.1021/jm070079j

Reference yield:

: 182133-15-9
[6-benzyloxy-3-[4-(2-(piperidin-1-yl)ethoxy)phenoxy]-2-(4-methoxyphenyl)]benzo[b]thiophene-(S-oxide)

: 182133-25-1
arzoxifene

Guidance literature:: [6-benzyloxy-3-[4-(2-(piperidin-1-yl)ethoxy)phenoxy]-2-(4-methoxyphenyl)]benzo[b]thiophene-(S-oxide); With sulfuric acid; In tetrahydrofuran; water;

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; water; at 30 ℃; for 26.5h; under 3102.97 Torr;

With sodium hydroxide; In tetrahydrofuran; water; for 0.5h; pH=7.24;