Methanesulfonic acid, trifluoro-, 7-[(1R)-2-hydroxy-1-[[(1R)-2-hydroxy-2-methyl-1-phenylpropyl]amino]eth yl]-5-(methoxymethoxy)-1,3-benzodioxol-4-yl ester

Base Information

Chemical Name:Methanesulfonic acid, trifluoro-, 7-[(1R)-2-hydroxy-1-[[(1R)-2-hydroxy-2-methyl-1-phenylpropyl]amino]eth yl]-5-(methoxymethoxy)-1,3-benzodioxol-4-yl ester
CAS No.:442663-42-5
Molecular Formula:C22H26F3NO9S
Molecular Weight:537.511
Hs Code.:

Methanesulfonic acid, trifluoro-,
7-[(1R)-2-hydroxy-1-[[(1R)-2-hydroxy-2-methyl-1-phenylpropyl]amino]eth
yl]-5-(methoxymethoxy)-1,3-benzodioxol-4-yl ester

Synonyms:

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Chemical Property of Methanesulfonic acid, trifluoro-, 7-[(1R)-2-hydroxy-1-[[(1R)-2-hydroxy-2-methyl-1-phenylpropyl]amino]eth yl]-5-(methoxymethoxy)-1,3-benzodioxol-4-yl ester

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MSDS Files:: SDS file from LookChem

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Technology Process of Methanesulfonic acid, trifluoro-, 7-[(1R)-2-hydroxy-1-[[(1R)-2-hydroxy-2-methyl-1-phenylpropyl]amino]eth yl]-5-(methoxymethoxy)-1,3-benzodioxol-4-yl ester

There total 5 articles about Methanesulfonic acid, trifluoro-, 7-[(1R)-2-hydroxy-1-[[(1R)-2-hydroxy-2-methyl-1-phenylpropyl]amino]eth yl]-5-(methoxymethoxy)-1,3-benzodioxol-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 442663-41-4
Trifluoro-methanesulfonic acid 7-((3R,5R)-6,6-dimethyl-2-oxo-5-phenyl-morpholin-3-yl)-5-methoxymethoxy-benzo[1,3]dioxol-4-yl ester

: 442663-42-5
Trifluoro-methanesulfonic acid 7-[(R)-2-hydroxy-1-((R)-2-hydroxy-2-methyl-1-phenyl-propylamino)-ethyl]-5-methoxymethoxy-benzo[1,3]dioxol-4-yl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h;
DOI:10.1021/ja026216d

Reference yield:

: 533-31-3
Sesamol

: 442663-42-5
Trifluoro-methanesulfonic acid 7-[(R)-2-hydroxy-1-((R)-2-hydroxy-2-methyl-1-phenyl-propylamino)-ethyl]-5-methoxymethoxy-benzo[1,3]dioxol-4-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / tetrahydrofuran; dimethylformamide; various solvent(s) / 0 - 20 °C

1.2: 97 percent / tetrahydrofuran; dimethylformamide; various solvent(s) / 0 - 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0 - 20 °C

2.2: 92 percent / aq. H₂O₂; trimethylboronate; AcOH / tetrahydrofuran; hexane / 4.5 h / 20 °C

3.1: 89 percent / TFA / CH₂Cl₂ / 2.17 h / -10 °C

4.1: 90 percent / pyridine / CH₂Cl₂ / 0.08 h / 0 °C

5.1: 85 percent / NaBH₄ / methanol / 0.5 h / 0 °C

With pyridine; sodium tetrahydroborate; n-butyllithium; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; 3.1: Mannich reaction;
DOI:10.1021/ja026216d

Reference yield:

: 111726-43-3
3,4-(methylenedioxy)phenyl methoxymethyl ether

: 442663-42-5
Trifluoro-methanesulfonic acid 7-[(R)-2-hydroxy-1-((R)-2-hydroxy-2-methyl-1-phenyl-propylamino)-ethyl]-5-methoxymethoxy-benzo[1,3]dioxol-4-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0 - 20 °C

1.2: 92 percent / aq. H₂O₂; trimethylboronate; AcOH / tetrahydrofuran; hexane / 4.5 h / 20 °C

2.1: 89 percent / TFA / CH₂Cl₂ / 2.17 h / -10 °C

3.1: 90 percent / pyridine / CH₂Cl₂ / 0.08 h / 0 °C

4.1: 85 percent / NaBH₄ / methanol / 0.5 h / 0 °C

With pyridine; sodium tetrahydroborate; n-butyllithium; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; 2.1: Mannich reaction;
DOI:10.1021/ja026216d