nitrile compound

Base Information

Chemical Name:nitrile compound
CAS No.:442663-56-1
Molecular Formula:C₄₈H₅₆Cl₃N₃O₉Si
Molecular Weight:953.432
Hs Code.:

Synonyms:nitrile compound

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Chemical Property of nitrile compound

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Technology Process of nitrile compound

There total 45 articles about nitrile compound which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 7677-24-9
trimethylsilyl cyanide

: 442663-35-6
(3R,5R,6R,12S,12aS)-2,2,2-trichloroethyl 7-(benzyloxy)-3-[6-(benzyloxy)-7-methylbenzo[d][1,3]dioxol-4-yl]-5-{[(tert-butyldimethylsilyl)oxy]methyl}-8-methoxy-9-methyl-3,5,6,11,12,12a-hexahydro-2H-6,12-epiminobenzo[e]oxazolo[3,2-a]azocine-13-carboxylate

: 442663-56-1
nitrile compound

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃;
DOI:10.1021/ja026216d

Reference yield:

: 442663-47-0
alcohol

: 442663-56-1
nitrile compound

Guidance literature:: Multi-step reaction with 20 steps

1: 93 percent / pyridine; DMAP / 30 h / 50 °C

2: TFA; anisole / CH₂Cl₂ / 9 h / 20 °C

3: 19.7 g / ethyl acetate / 1 h / Heating

4: 91 percent / TEA / CH₂Cl₂ / 1 h / 0 °C

5: 97 percent / DMAP / acetonitrile / 6.5 h / 20 °C

6: NaBH₄; H₂SO₄ / ethanol; CH₂Cl₂ / 0 °C

7: 3.54 g / CSA; quinoline / toluene / 3 h / Heating

8: 83 percent / tris(dibenzylideneacetone)dipalladium⁽⁰⁾; tris(o-tolyl)phosphine; TEA / acetonitrile / 2 h / Heating

9: aq. NaOH / methanol / 2.5 h / Heating

10: 106 mg / pyridine; DMAP / CH₂Cl₂ / 20 °C

11: TFA / CH₂Cl₂ / 4 h / 20 °C

12: 2.08 g / NaHCO₃ / CH₂Cl₂; H₂O / 0.17 h / 0 °C

13: dimethyldioxirane / methanol; acetone / 2 h / 0 °C

14: 652 mg / CSA / acetone / 0 - 20 °C

15: 94 percent / sodium cyanoborohydride; TFA / tetrahydrofuran / 0.5 h / 0 °C

16: 92 percent / imidazole / dimethylformamide / 2 h / 20 °C

17: 85 percent / guanidinium nitrate; NaOMe / methanol; CH₂Cl₂ / 2.5 h / 40 °C

18: 91 percent / K₂CO₃ / acetonitrile / 1 h / Heating

19: 82 percent / Red-Al / tetrahydrofuran; toluene / 0 °C

20: 73 percent / BF₃*OEt₂ / CH₂Cl₂ / 0 °C

With pyridine; 1H-imidazole; quinoline; dmap; sodium hydroxide; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; guanidinium nitrate; TEA; sulfuric acid; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; sodium methylate; 3,3-dimethyldioxirane; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; methoxybenzene; sodium bis(2-methoxyethoxy)aluminium dihydride; tris-(o-tolyl)phosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; 8: Heck reaction;
DOI:10.1021/ja026216d

Reference yield:

: 533-31-3
Sesamol

: 442663-56-1
nitrile compound

Guidance literature:: Multi-step reaction with 31 steps

1.1: NaH / tetrahydrofuran; dimethylformamide; various solvent(s) / 0 - 20 °C

1.2: 97 percent / tetrahydrofuran; dimethylformamide; various solvent(s) / 0 - 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0 - 20 °C

2.2: 92 percent / aq. H₂O₂; trimethylboronate; AcOH / tetrahydrofuran; hexane / 4.5 h / 20 °C

3.1: 89 percent / TFA / CH₂Cl₂ / 2.17 h / -10 °C

4.1: 90 percent / pyridine / CH₂Cl₂ / 0.08 h / 0 °C

5.1: 85 percent / NaBH₄ / methanol / 0.5 h / 0 °C

6.1: 91 percent / imidazole / dimethylformamide / 20 °C

7.1: 97 percent / PdCl₂(dppf) / tetrahydrofuran / 4.5 h / Heating

8.1: Pb(OAc)4 / acetonitrile / 0 °C

9.1: 436 mg / NH₂OH*HCl; NaOAc / ethanol / 1.5 h / 20 °C

10.1: 90 percent / methanol / 1 h / Heating

11.1: 89 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

12.1: 93 percent / pyridine; DMAP / 30 h / 50 °C

13.1: TFA; anisole / CH₂Cl₂ / 9 h / 20 °C

14.1: 19.7 g / ethyl acetate / 1 h / Heating

15.1: 91 percent / TEA / CH₂Cl₂ / 1 h / 0 °C

16.1: 97 percent / DMAP / acetonitrile / 6.5 h / 20 °C

17.1: NaBH₄; H₂SO₄ / ethanol; CH₂Cl₂ / 0 °C

18.1: 3.54 g / CSA; quinoline / toluene / 3 h / Heating

19.1: 83 percent / tris(dibenzylideneacetone)dipalladium⁽⁰⁾; tris(o-tolyl)phosphine; TEA / acetonitrile / 2 h / Heating

20.1: aq. NaOH / methanol / 2.5 h / Heating

21.1: 106 mg / pyridine; DMAP / CH₂Cl₂ / 20 °C

22.1: TFA / CH₂Cl₂ / 4 h / 20 °C

23.1: 2.08 g / NaHCO₃ / CH₂Cl₂; H₂O / 0.17 h / 0 °C

24.1: dimethyldioxirane / methanol; acetone / 2 h / 0 °C

25.1: 652 mg / CSA / acetone / 0 - 20 °C

26.1: 94 percent / sodium cyanoborohydride; TFA / tetrahydrofuran / 0.5 h / 0 °C

27.1: 92 percent / imidazole / dimethylformamide / 2 h / 20 °C

28.1: 85 percent / guanidinium nitrate; NaOMe / methanol; CH₂Cl₂ / 2.5 h / 40 °C

29.1: 91 percent / K₂CO₃ / acetonitrile / 1 h / Heating

30.1: 82 percent / Red-Al / tetrahydrofuran; toluene / 0 °C

31.1: 73 percent / BF₃*OEt₂ / CH₂Cl₂ / 0 °C

With pyridine; 1H-imidazole; quinoline; lead(IV) acetate; dmap; sodium hydroxide; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; guanidinium nitrate; TEA; sulfuric acid; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; sodium methylate; sodium acetate; 3,3-dimethyldioxirane; sodium hydride; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; methoxybenzene; sodium bis(2-methoxyethoxy)aluminium dihydride; tris-(o-tolyl)phosphine; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; 3.1: Mannich reaction / 10.1: Ugi reaction / 19.1: Heck reaction;
DOI:10.1021/ja026216d