(3-benzoyl-1-methyl-4-phenyl-4-piperidyl) acetate

Base Information

• Chemical Name: (3-benzoyl-1-methyl-4-phenyl-4-piperidyl) acetate
• CAS No.: 6636-24-4
• Molecular Formula: C21H23 N O3
• Molecular Weight: 337.41
• Mol file: 6636-24-4.mol

Synonyms:Ketone,4-hydroxy-1-methyl-4-phenyl-3-piperidyl phenyl, acetate (ester) (8CI); NSC49902

Chemical Property of (3-benzoyl-1-methyl-4-phenyl-4-piperidyl) acetate

Chemical Property:

• Vapor Pressure: 1.64E-08mmHg at 25°C
• Boiling Point: 456.3°C at 760 mmHg
• Flash Point: 229.8°C
• PSA: 46.61000
• Density: 1.17g/cm³
• LogP: 3.21750

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-benzoyl-1-methyl-4-phenyl-4-piperidyl) acetate

There total 3 articles about (3-benzoyl-1-methyl-4-phenyl-4-piperidyl) acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine (5409-66-5) + acetyl chloride (75-36-5) → Acetic acid 3-benzoyl-1-methyl-4-phenyl-piperidin-4-yl ester (6636-24-4)

Guidance literature:

In chloroform; at 50 ℃;

DOI:10.1016/0223-5234(89)90026-3

Reference yield:

acetophenone (98-86-2) → Acetic acid 3-benzoyl-1-methyl-4-phenyl-piperidin-4-yl ester (6636-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / ethanol / 5 h / Heating

2: 53 percent / CHCl₃ / 50 °C

In ethanol; chloroform;

DOI:10.1016/0223-5234(89)90026-3

Reference yield:

3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine (5409-66-5,21499-56-9) + acetic anhydride (108-24-7) → (4c-acetoxy-1-methyl-4t-phenyl-[3r]piperidyl)-phenyl ketone (6636-24-4)

Guidance literature:

With sulfuric acid;

DOI:10.1021/jo01156a007

upstream raw materials:

3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine

acetic anhydride

3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine

acetyl chloride