FMOC-4-AMINOBENZYLALCOHOL

Base Information

• Chemical Name: FMOC-4-AMINOBENZYLALCOHOL
• CAS No.: 475160-83-9
• Molecular Formula: C22H19NO3
• Molecular Weight: 345.398
• Mol file: 475160-83-9.mol

Synonyms:FMOC-4-aminobenzylalcohol;4-(hydroxymethyl)phenylcarbamic acid 9H-fluoren-9-ylmethyl ester;(4-hydroxymethylphenyl)carbamic acid 9H-fluoren-9-ylmethyl ester;(4-hydroxymethyl-phenyl)-carbamic acid 9H-fluoren-9-ylmethyl ester;

Chemical Property of FMOC-4-AMINOBENZYLALCOHOL

Chemical Property:

• Melting Point: 185 °C(Solv: toluene (108-88-3); ethyl acetate (141-78-6))
• Boiling Point: 520.4±38.0 °C(Predicted)
• PKA: 13.05±0.70(Predicted)
• PSA: 58.56000
• Density: 1.293±0.06 g/cm3(Predicted)
• LogP: 4.61290
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

(9H-Fluoren-9-yl)methyl(4-(hydroxymethyl)phenyl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-4-AMINOBENZYLALCOHOL

There total 3 articles about FMOC-4-AMINOBENZYLALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-aminobenzenemethanol (623-04-1) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → (4-hydroxymethylphenyl)carbamic acid 9H-fluoren-9-ylmethyl ester (475160-83-9)

Guidance literature:

With sodium hydrogencarbonate; In water; acetonitrile; at 20 ℃; Cooling with ice;

DOI:10.1021/acs.jmedchem.0c02042

Reference yield: 87.0%

4-aminobenzenemethanol (623-04-1) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → (4-hydroxymethylphenyl)carbamic acid 9H-fluoren-9-ylmethyl ester (475160-83-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2007.10.110

Reference yield: 66.0%

→ (4-hydroxymethylphenyl)carbamic acid 9H-fluoren-9-ylmethyl ester (475160-83-9)

Guidance literature:

upstream raw materials:

4-aminobenzenemethanol

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(fluorenylmethoxy)carbonyl chloride

Downstream raw materials:

(4-chloromethyl-phenyl)-carbamic acid 9H-fluoren-9-ylmethyl ester