N,N-Bis(2-hydroxyethyl)hexadecanamide

Base Information

• Chemical Name: N,N-Bis(2-hydroxyethyl)hexadecanamide
• CAS No.: 7545-24-6
• Deprecated CAS: 1451152-21-8,1929606-28-9,1929606-28-9
• Molecular Formula: C20H41 N O3
• Molecular Weight: 343.55
• Hs Code.: 2924199090
• European Community (EC) Number: 231-427-2
• UNII: SZ3923Q89F
• DSSTox Substance ID: DTXSID701022468,DTXSID90880419
• Nikkaji Number: J115.268H
• Wikidata: Q27289474
• ChEMBL ID: CHEMBL2238330
• Mol file: 7545-24-6.mol

Synonyms:7545-24-6;N,N-Bis(2-hydroxyethyl)hexadecanamide;N,N-Bis(2-hydroxyethyl)palmitamide;Palmitamide DEA;Palmitic diethanolamide;N,N-Bis(2-hydroxyethyl)hexadecan-1-amide;Hexadecanamide, N,N-bis(2-hydroxyethyl)-;Palmitic acid diethanolamide;EINECS 231-427-2;C15DEA;Palmitic acid, diethanolamide;UNII-SZ3923Q89F;Diethanolamine palmitic acid amide;SZ3923Q89F;PALMITYLDIETHANOLAMIDE;SCHEMBL284784;PALMITOYL DIETHANOLAMIDE;N,N-DIETHYLOLPALMITAMIDE;PALMITAMIDE DEA [INCI];CHEMBL2238330;DTXSID90880419;DTXSID701022468;ADAL1018712;MFCD28971954;AKOS037645875;Hexadecanamide,N,N-bis(2-hydroxyethyl)-;AS-64394;N,N-BIS(2-HYDROXYETHYL)-PALMITAMIDE;D81526;N, N- bis(2- hydroxyethyl)hexadecan- 1- amide;Q27289474

Chemical Property of N,N-Bis(2-hydroxyethyl)hexadecanamide

Chemical Property:

• Boiling Point: 492.5oC at 760 mmHg
• Flash Point: 251.7oC
• PSA: 60.77000
• Density: 0.959 g/cm3
• LogP: 4.28090
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 5.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 18
• Exact Mass: 343.30864417
• Heavy Atom Count: 24
• Complexity: 266

Purity/Quality:

99%, ^*data from raw suppliers

N,N-BIS-(2-HYDROXYETHYL)HEXADECANAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCCCCC(=O)N(CCO)CCO

Technology Process of N,N-Bis(2-hydroxyethyl)hexadecanamide

There total 5 articles about N,N-Bis(2-hydroxyethyl)hexadecanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,2'-iminobis[ethanol] (111-42-2) + n-hexadecanoyl chloride (112-67-4) → N,N-bis(2-hydroxyethyl)palmitamide (7545-24-6)

Guidance literature:

With magnesium oxide; In tetrahydrofuran; water; at 20 ℃; for 2h;

DOI:10.1016/S0040-4039(01)02134-7

Reference yield: 80.71%

hexadecanoic acid methyl ester (112-39-0) + 2,2'-iminobis[ethanol] (111-42-2) → N,N-bis(2-hydroxyethyl)palmitamide (7545-24-6)

Guidance literature:

With sodium hydroxide; at 110 ℃; for 5h;

Reference yield: 67.0%

2,2'-iminobis[ethanol] (111-42-2) + 1-hexadecylcarboxylic acid (57-10-3) → N,N-bis(2-hydroxyethyl)palmitamide (7545-24-6)

Guidance literature:

1-hexadecylcarboxylic acid; With triethylamine; methyl chloroformate; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;

2,2'-iminobis[ethanol]; In dichloromethane; at 20 ℃;

DOI:10.1007/s00044-010-9357-7

upstream raw materials:

2,2'-iminobis[ethanol]

1-hexadecylcarboxylic acid

n-hexadecanoyl chloride

hexadecanoic acid methyl ester

Downstream raw materials:

2,2'-iminobis[ethanol]

1-hexadecylcarboxylic acid

Refernces

• 1、 -. "Oil soluble molybdenum amine complex and preparation method thereof". Paragraph 0034. . Retrieved 2017/07/19.
• 2、 Xun, Miao-Miao,Zhang, Xue-Chao,Zhang, Ji,Jiang, Qian-Qian,Yi, Wen-Jing,Zhu, Wen,Yu, Xiao-Qi. "Low molecular weight PEI-based biodegradable lipopolymers as gene delivery vectors". . p. 1242 - 1250. Retrieved 2013/03/29.