Formaldehyde

Base Information

• Chemical Name: Formaldehyde
• CAS No.: 30525-89-4
• Deprecated CAS: 112068-71-0,8005-38-7,8006-07-3,8013-13-6,1053659-79-2,1156543-56-4,1158237-02-5,1227476-28-9,1357848-44-2,1416946-65-0,1609158-91-9,1196157-74-0,2100305-91-5,1053659-79-2,1156543-56-4,1158237-02-5,1227476-28-9,8005-38-7,8006-07-3,8013-13-6
• Molecular Formula: CH₂O
• Molecular Weight: 30.0263
• Hs Code.: 38084090
• European Community (EC) Number: 200-001-8,685-227-9
• ICSC Number: 0275
• NSC Number: 298885
• UN Number: 3077,1198,2209
• UNII: 1HG84L3525
• DSSTox Substance ID: DTXSID7020637
• Nikkaji Number: J2.294B,J369.708H
• Wikipedia: Formaldehyde
• Wikidata: Q161210,Q27110014
• NCI Thesaurus Code: C29744
• RXCUI: 4530
• Pharos Ligand ID: GLZFC5QP99RT
• Metabolomics Workbench ID: 50670
• ChEMBL ID: CHEMBL1255
• Mol file: 30525-89-4.mol

Synonyms:Formaldehyde;Formalin;Formol;Methanal;Oxomethane

Chemical Property of Formaldehyde

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: <1.45 mm Hg ( 25 °C)
• Melting Point: 120-170 °C
• Refractive Index: 1.339
• Boiling Point: 6.8°C at 760 mmHg
• Flash Point: 71 °C
• PSA: 17.07000
• Density: 0.88 g/cm³
• LogP: 0.45100
• Storage Temp.: 2-8°C
• Solubility.: chlorophenol above 70°C: soluble
• Water Solubility.: sparingly soluble
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 30.010564683
• Heavy Atom Count: 2
• Complexity: 2
• Transport DOT Label: Class 9

Purity/Quality:

99% ^*data from raw suppliers

Paraformaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,F
• Statements: 31-43-40-36/37/38-20/22-41-37/38-42/43-20/21/22-11
• Safety Statements: 36-45-36/37/39-26-24-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Aldehydes
• Canonical SMILES: C=O
• Recent NIPH Clinical Trials: Assessment of Evaluation of tumor cell content ratio using endocytoscopy in biopsy tissue.
• Inhalation Risk: A harmful concentration of this gas in the air will be reached very quickly on loss of containment.
• Effects of Short Term Exposure: The substance is severely irritating to the eyes and respiratory tract. Inhalation of high concentrations may cause lung oedema, but only after initial corrosive effects on the eyes and the upper respiratory tract have become manifest.
• Effects of Long Term Exposure: Repeated or chronic inhalation of the vapour may cause chronic inflammation of the upper respiratory tract. Repeated or prolonged contact may cause skin sensitization. This substance is carcinogenic to humans.
• Uses: Paraformaldehyde is used as a fumigant, a disinfectant and in the manufacture of synthetic resins like melamine resin, phenol resin and polyacetal resin. It is also used in cell culture. It also serves as a fixative in electron microscopy. It is also used in the preparation of formalin fixatives for tissues or cells. To use the chemical as a fixative, it must be converted to the monomer formaldehyde by heating as formaldehyde is the active chemical in fixation.

Technology Process of Formaldehyde

There total 1561 articles about Formaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

p-nitro-N,N-dimethylaniline-N-oxide (26492-31-9) → formaldehyd (50-00-0,30525-89-4,61233-19-0) + N,N-Dimethyl-4-nitroaniline (100-23-2)

Guidance literature:

With 1H-imidazole; meso-tetraphenylporphyrin iron(III) chloride; DMA-OCH₃; In chloroform; at 25 ℃; for 0.5h;

DOI:10.1016/S0040-4039(00)84329-4

Reference yield: 2.1%

butyl-[1,2,4]trioxolane (767-09-9) → formaldehyd (50-00-0,30525-89-4,61233-19-0) + pentanal (110-62-3) + Dimethoxymethane (109-87-5) + Methyl formate (107-31-3) + 1,1-dimethoxy-pentane (26450-58-8) + valeric acid (109-52-4)

Guidance literature:

In methanol; at 90 ℃; for 6h; Mechanism; Product distribution;

Reference yield:

1-(1-chloroethenyl)-4-methoxybenzene (40811-01-6) → formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-methoxybenzoic acid (100-09-4)

Guidance literature:

Einleiten von Sauerstoff; Behandeln des Reaktionsprodukts mit Wasser;

upstream raw materials:

oxirane

ethene

benzene

diazomethane

Downstream raw materials:

2-(piperidin-1-ylmethyl)pyridin-3-ol

N-Piperidinomethyl-succinimid

1-Piperidinomethyl-benzimidazol

2-methyl-3-piperidinomethyl-indole

Refernces

• 1、 Wibaut,Geerling. "". . p. 41. Retrieved 1931.
• 2、 Wada, Kenji,Yoshida, Kyomi,Watanabe, Yoshihisa. "Selective Photooxidation of Light Alkanes to Oxygenates using Supported Molybdenum Oxide Catalysts". . p. 1647 - 1654. Retrieved 1995.
• 3、 Brock, Eric E.,Oshima, Yoshito,Savage, Phillip E.,Barker, John R.. "Kinetics and Mechanism of Methanol Oxidation in Supercritical Water". . p. 15834 - 15842. Retrieved 1996.
• 4、 Milligan, D. E.,Jacox, M. E.. "". . p. 4487 - 4493. Retrieved 1965.
• 5、 Bone,Wheeler. "-". . . Retrieved 1904.
• 6、 Beckett,Hua. "Elucidation of the 1,4-dioxane decomposition pathway at discrete ultrasonic frequencies". . p. 3944 - 3953. Retrieved 2000.
• 7、 Djehiche, Mokhtar,Le Tan, Ngoc Linh,Jain, Chaithanya D.,Dayma, Guillaume,Dagaut, Philippe,Chauveau, Christian,Pillier, Laure,Tomas, Alexandre. "Quantitative measurements of HO2 and other products of n -butane oxidation (H2O2, H2O, CH2O, and C2H4) at elevated temperatures by direct coupling of a jet-stirred reactor with sampling nozzle and cavity ring-down spectroscopy (cw-CRDS)". . p. 16689 - 16694. Retrieved 2014.
• 8、 Traube,W.. "-". . p. 107. Retrieved 1898.
• 9、 Kass, Steven, R.,Filley, Jonathan,Doren, Jane M. Van,DePuy, Charles H.. "Nitrous Oxide in Gas-Phase Ion-Molecule Chemistry: A Versatile Reagent for the Determination of Carbanion Structure". . p. 2849 - 2852. Retrieved 1986.
• 10、 Han, Li-Biao,Tsubota, Susumu,Haruta, Masatake. "Effect of the Addition of Nitrogen Dioxide on the Gas-Phase Partial Oxidation of Methane with Oxygen under Normal Pressures". . p. 931 - 932. Retrieved 1995.