2,8,13,21,23-Tetracosapentaenoic acid, 19-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,11,17-tris[(4-methoxyphenyl) methoxy]-4,10,12,18,20-pentamethyl-, ethyl ester, (2E,4R,5R,8Z,10S,11S,12S,13Z,17R,18S,19S,20S,21Z)-

Base Information

Chemical Name:2,8,13,21,23-Tetracosapentaenoic acid, 19-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,11,17-tris[(4-methoxyphenyl) methoxy]-4,10,12,18,20-pentamethyl-, ethyl ester, (2E,4R,5R,8Z,10S,11S,12S,13Z,17R,18S,19S,20S,21Z)-
CAS No.:479673-33-1
Molecular Formula:C61H90O9Si
Molecular Weight:995.466
Hs Code.:

2,8,13,21,23-Tetracosapentaenoic acid,
19-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,11,17-tris[(4-methoxyphenyl)
methoxy]-4,10,12,18,20-pentamethyl-, ethyl ester,
(2E,4R,5R,8Z,10S,11S,12S,13Z,17R,18S,19S,20S,21Z)-

Synonyms:

Suppliers and Price of 2,8,13,21,23-Tetracosapentaenoic acid, 19-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,11,17-tris[(4-methoxyphenyl) methoxy]-4,10,12,18,20-pentamethyl-, ethyl ester, (2E,4R,5R,8Z,10S,11S,12S,13Z,17R,18S,19S,20S,21Z)-

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Chemical Property of 2,8,13,21,23-Tetracosapentaenoic acid, 19-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,11,17-tris[(4-methoxyphenyl) methoxy]-4,10,12,18,20-pentamethyl-, ethyl ester, (2E,4R,5R,8Z,10S,11S,12S,13Z,17R,18S,19S,20S,21Z)-

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Technology Process of 2,8,13,21,23-Tetracosapentaenoic acid, 19-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,11,17-tris[(4-methoxyphenyl) methoxy]-4,10,12,18,20-pentamethyl-, ethyl ester, (2E,4R,5R,8Z,10S,11S,12S,13Z,17R,18S,19S,20S,21Z)-

There total 22 articles about 2,8,13,21,23-Tetracosapentaenoic acid, 19-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,11,17-tris[(4-methoxyphenyl) methoxy]-4,10,12,18,20-pentamethyl-, ethyl ester, (2E,4R,5R,8Z,10S,11S,12S,13Z,17R,18S,19S,20S,21Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 479673-54-6
(2E,8Z)-(4R,5R,10S,11S,12R)-5,11-Bis-(4-methoxy-benzyloxy)-4,10,12-trimethyl-13-oxo-trideca-2,8-dienoic acid ethyl ester

: (Z)-(4R,5S,6S,7S)-[6-(tert-butyldimethylsilanyloxy)-4-(4-methoxybenzyloxy)-5,7-dimethylundeca-8,10-dienyl]triphenylphosphonium iodide

: 479673-33-1
(4R, [5R,] 10S, [11S,] 12S, [17R,] [18R,] [19R,] 205)-19-(TERT-BUTYLDIMETHYLSILANYLOXY)-5,11, [17-TRIS-(4-METHOXYBENZYLOXY)-4, 10,] 12,18, 20-pentamethyltetracosa-2,8, 13, 21,23-pentaenoic acid ethyl ester

Guidance literature:: With sodium hexamethyldisilazane;
DOI:10.1021/ol026942l

Reference yield:

: 154919-93-4
(S)-4-Benzyl-3-[(2S,3R)-6-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2-methyl-hexanoyl]-oxazolidin-2-one

: 479673-33-1
(4R, [5R,] 10S, [11S,] 12S, [17R,] [18R,] [19R,] 205)-19-(TERT-BUTYLDIMETHYLSILANYLOXY)-5,11, [17-TRIS-(4-METHOXYBENZYLOXY)-4, 10,] 12,18, 20-pentamethyltetracosa-2,8, 13, 21,23-pentaenoic acid ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: LiBH₄

1.2: PPTS

2.1: 92 percent / DIBAL

3.1: Dess-Martin periodinane

4.1: NaH

5.1: 84 percent / HF*pyridine

6.1: 72 percent / Dess-Martin periodinane

7.1: 74 percent / NaHMDS

8.1: 68 percent / NaCNBH₃; TMSCl

9.1: 89 percent / Dess-Martin periodinane

10.1: 48 percent / NaHMDS

With lithium borohydride; chloro-trimethyl-silane; sodium hexamethyldisilazane; sodium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; Dess-Martin periodane; pyridine hydrogenfluoride; 3.1: Dess-Martin oxidation / 4.1: Wittig-Horner reaction / 6.1: Dess-Martin oxidation / 7.1: Wittig reaction / 9.1: Dess-Martin oxidation / 10.1: Wittig reaction;
DOI:10.1021/ol026942l

Reference yield:

: 479673-49-9
(4R,5R)-tert-butyl-{3-[2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propoxy}dimethylsilane

: 479673-33-1
(4R, [5R,] 10S, [11S,] 12S, [17R,] [18R,] [19R,] 205)-19-(TERT-BUTYLDIMETHYLSILANYLOXY)-5,11, [17-TRIS-(4-METHOXYBENZYLOXY)-4, 10,] 12,18, 20-pentamethyltetracosa-2,8, 13, 21,23-pentaenoic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 92 percent / DIBAL

2: Dess-Martin periodinane

3: NaH

4: 84 percent / HF*pyridine

5: 72 percent / Dess-Martin periodinane

6: 74 percent / NaHMDS

7: 68 percent / NaCNBH₃; TMSCl

8: 89 percent / Dess-Martin periodinane

9: 48 percent / NaHMDS

With chloro-trimethyl-silane; sodium hexamethyldisilazane; sodium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; Dess-Martin periodane; pyridine hydrogenfluoride; 2: Dess-Martin oxidation / 3: Wittig-Horner reaction / 5: Dess-Martin oxidation / 6: Wittig reaction / 8: Dess-Martin oxidation / 9: Wittig reaction;
DOI:10.1021/ol026942l