Technology Process of 2-Octenoic acid,
8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]-4-
methyl-, ethyl ester, (2E,4R,5R)-
There total 7 articles about 2-Octenoic acid,
8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]-4-
methyl-, ethyl ester, (2E,4R,5R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diethoxyphosphoryl-acetic acid ethyl ester;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
for 0.666667h;
(2S,3R)-6-(tert-butyldimethylsilanyloxy)-3-(4-methoxybenzyloxy)-2-methylhexanal;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 81 percent / Py*SO3; Et3N / CH2Cl2; dimethylsulfoxide
2.1: 95 percent / n-Bu2BOTf; DIPEA
3.1: LiBH4
3.2: PPTS
4.1: 92 percent / DIBAL
5.1: Dess-Martin periodinane
6.1: NaH
With
lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; sulfur trioxide pyridine complex; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; dimethyl sulfoxide;
2.1: Evans syn-aldol reaction / 5.1: Dess-Martin oxidation / 6.1: Wittig-Horner reaction;
DOI:10.1021/ol026942l
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 96 percent / NaH
2.1: 81 percent / Py*SO3; Et3N / CH2Cl2; dimethylsulfoxide
3.1: 95 percent / n-Bu2BOTf; DIPEA
4.1: LiBH4
4.2: PPTS
5.1: 92 percent / DIBAL
6.1: Dess-Martin periodinane
7.1: NaH
With
lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; sulfur trioxide pyridine complex; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; dimethyl sulfoxide;
3.1: Evans syn-aldol reaction / 6.1: Dess-Martin oxidation / 7.1: Wittig-Horner reaction;
DOI:10.1021/ol026942l
