Technology Process of Hexanal,
6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[(4-methoxyphenyl)methoxy]-2-
methyl-, (2S,3R)-
There total 7 articles about Hexanal,
6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[(4-methoxyphenyl)methoxy]-2-
methyl-, (2S,3R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; dimethyl sulfoxide;
at 20 ℃;
for 1h;
DOI:10.1021/jm0204136
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / lithium borohydride / methanol; tetrahydrofuran / 2.33 h / 0 - 20 °C
2: 72 percent / pyridinium p-toluenesulfonate / benzene / 15 h / Heating
3: diisobutylaluminum hydride / tetrahydrofuran; CH2Cl2 / 1 h / 0 °C
4: pyridinium sulfur trioxide; diisopropylethylamine / dimethylsulfoxide; CH2Cl2 / 1 h / 20 °C
With
lithium borohydride; sulfur trioxide pyridine complex; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; benzene;
1: Evans syn-aldol condensation;
DOI:10.1021/jm0204136
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 95 percent / pyridinium sulfur trioxide
2: 95 percent / lithium borohydride / methanol; tetrahydrofuran / 2.33 h / 0 - 20 °C
3: 72 percent / pyridinium p-toluenesulfonate / benzene / 15 h / Heating
4: diisobutylaluminum hydride / tetrahydrofuran; CH2Cl2 / 1 h / 0 °C
5: pyridinium sulfur trioxide; diisopropylethylamine / dimethylsulfoxide; CH2Cl2 / 1 h / 20 °C
With
lithium borohydride; sulfur trioxide pyridine complex; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; benzene;
3: Evans syn-aldol condensation;
DOI:10.1021/jm0204136
