1,2-dimethyl-5-phenyl-1H-pyrazol-3(2H)-one

Base Information

Chemical Name:1,2-dimethyl-5-phenyl-1H-pyrazol-3(2H)-one
CAS No.:486-38-4
Molecular Formula:C11H12N2O
Molecular Weight:188.229
Hs Code.:
DSSTox Substance ID:DTXSID00574150
Nikkaji Number:J61.240E
Wikidata:Q82463089
Mol file:486-38-4.mol

Synonyms:486-38-4;1,2-dimethyl-5-phenyl-1H-pyrazol-3(2H)-one;SCHEMBL1964715;DTXSID00574150;IQECATHPQKKYCK-UHFFFAOYSA-N;1,2-Dimethyl-5-phenyl-1,2-dihydro-3H-pyrazol-3-one

Suppliers and Price of 1,2-dimethyl-5-phenyl-1H-pyrazol-3(2H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 5 raw suppliers

Chemical Property of 1,2-dimethyl-5-phenyl-1H-pyrazol-3(2H)-one

Chemical Property:

PSA：26.93000
LogP:1.39080
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:188.094963011
Heavy Atom Count:14
Complexity:267

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=CC(=O)N1C)C2=CC=CC=C2

Technology Process of 1,2-dimethyl-5-phenyl-1H-pyrazol-3(2H)-one

There total 10 articles about 1,2-dimethyl-5-phenyl-1H-pyrazol-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 138211-83-3
N'-acetyl-N,N'-dimethylbenzohydrazide

: 486-38-4
1,2-dimethyl-5-phenyl-1,2-dihydro-pyrazol-3-one

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1) -78 deg C, 30 min, 2) RT, 3) 60 min, reflux;
DOI:10.1055/s-1991-26588

Reference yield: 21.0%

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 486-38-4
1,2-dimethyl-5-phenyl-1,2-dihydro-pyrazol-3-one

Guidance literature:: N,N'-Dimethylhydrazine dihydrochloride; With sodium hydroxide; In water; for 0.166667h;

ethyl 3-oxo-3-phenylpropionate; With acetic acid; In water; at 115 ℃;

Reference yield:

: 13466-32-5
acetophenone dimethylhydrazone

: 486-38-4
1,2-dimethyl-5-phenyl-1,2-dihydro-pyrazol-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 20 percent / Et₃N / acetonitrile / 5 h / 20 °C

2: 400 °C

With triethylamine; In acetonitrile;
DOI:10.1039/b304070d