1,2-Dimethylhydrazine dihydrochloride

Base Information

• Chemical Name: 1,2-Dimethylhydrazine dihydrochloride
• CAS No.: 306-37-6
• Molecular Formula: C2H8N2.2ClH
• Molecular Weight: 133.021
• Hs Code.: 29280090
• European Community (EC) Number: 206-183-5
• UN Number: 2811
• UNII: 8326154U0N
• DSSTox Substance ID: DTXSID6020517
• Wikidata: Q27144091
• NCI Thesaurus Code: C29788
• Metabolomics Workbench ID: 66625
• ChEMBL ID: CHEMBL1203772
• Mol file: 306-37-6.mol

Synonyms:1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE;306-37-6;N,N'-Dimethylhydrazine dihydrochloride;1,2-Dimethylhydrazine 2HCl;Hydrazine, 1,2-dimethyl-, dihydrochloride;1,2-Dimethylhydrazinium dichloride;sym-Dimethylhydrazine dihydrochloride;Dimethylhydrazinium dichloride;1,2-Dimethylhydrazine.2HCl;CCRIS 260;EINECS 206-183-5;1,2-dimethylhydrazine;dihydrochloride;NSC 60518;DTXSID6020517;CHEBI:73759;UNII-8326154U0N;1,2-Dimethyl hydrazine dihydrochloride;8326154U0N;Hydrazine, 1,2-dimethyl-, hydrochloride (1:2);Dimethylhydrazine dihydrochloride;NSC-60518;MeNHNHMe.2HCl;C2H8N2.2ClH;DTXCID80517;SCHEMBL135630;SPECTRUM1502116;CHEMBL1203772;dimethylhydrazine, dihydrochloride;WLDRFJDGKMTPPV-UHFFFAOYSA-N;N,N'-Dimethylhydrazinium dichloride;Tox21_201194;1,2-Dimethyl-hydrazine Hydrochloride;MFCD00012522;N,N'-Dimethy lhydrazinium dichloride;N,N'-Dimethylhydrazinedihydrochloride;1,2,-dimethylhydrazine dihydrochloride;1,2-dimethyl-hydrazine dihydrochloride;1,2-dimethylhydrazine, dihydrochloride;AKOS015900419;1,1'-Dimethylhydrazine Dihydrochloride;CCG-214645;LS-1161;N,N'-dimethyl-hydrazine dihydrochloride;NCGC00095283-01;NCGC00095283-02;NCGC00258746-01;AS-47601;CAS-306-37-6;PD001376;CS-0530458;D0741;FT-0600336;N,N'-Dimethylhydrazine dihydrochloride, 98%;F14608;A820465;J-018043;Q27144091;1H-Pyrrole-2-propanoic acid, .beta.-oxo-, ethyl ester

Chemical Property of 1,2-Dimethylhydrazine dihydrochloride

Chemical Property:

• Appearance/Colour: SOLID
• Vapor Pressure: 168mmHg at 25°C
• Melting Point: 167-169 °C
• Boiling Point: 81.5 °C at 760 mmHg
• Flash Point: 1.1°C
• PSA: 24.06000
• Density: 0.759 g/cm3
• LogP: 1.72600
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: almost transparency
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 132.0221037
• Heavy Atom Count: 6
• Complexity: 6
• Transport DOT Label: Poison

Purity/Quality:

97% ^*data from raw suppliers

1,2-Dimethylhydrazine Dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T,N
• Hazard Codes: T,N
• Statements: 45-23/24/25-51/53
• Safety Statements: 53-45-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Hydrazines
• Canonical SMILES: CNNC.Cl.Cl
• Uses: carcinogen 1,2-Dimethylhydrazine is a potent carcinogen that acts as a DNA alkylating agent. It is used to induce colon tumors in experimental animals. It was also used in preparation of spiroisoquinolinedione aldose reductase inhibitors.

Technology Process of 1,2-Dimethylhydrazine dihydrochloride

There total 2 articles about 1,2-Dimethylhydrazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

hydrogenchloride (7647-01-0,15364-23-5) + C44H82N6Sc2 → C42H76Cl2N4Sc2 + N,N'-Dimethylhydrazine dihydrochloride (306-37-6)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1021/jacs.9b04293

Reference yield:

methylamine (74-89-5) → N,N'-Dimethylhydrazine dihydrochloride (306-37-6)

Guidance literature:

methylamine; With triethylamine; In dichloromethane; for 0.25h;

With bis(trichloromethyl) carbonate; In dichloromethane; at -5 - 0 ℃; for 1h;

DOI:10.1021/acs.orglett.1c01111

Reference yield: 97.0%

N-Cbz-L-Phe (1161-13-3) + N,N'-Dimethylhydrazine dihydrochloride (306-37-6) → (S)-benzyl (1-(1,2-dimethylhydrazinyl)-1-oxo-3-phenylpropan-2-yl)carbamate (1043922-50-4)

Guidance literature:

N-Cbz-L-Phe; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -25 ℃;

N,N'-Dimethylhydrazine dihydrochloride; With sodium hydroxide; In tetrahydrofuran; water; at -25 - 20 ℃; for 2h;

DOI:10.1002/anie.200705858

upstream raw materials:

hydrogenchloride

methylamine

Downstream raw materials:

2,3-dimethyl-1,2,3,4-tetrahydrophthalazine-1,4-dione

(Z)-azomethane

2,3-dimethyl-1,1-dioxo-6-phenyl-1λ⁶-[1,2,3,7]thiatriazepan-4-one

6β-(2-phenyl-acetylamino)-penicillanic acid N,N'-dimethyl-hydrazide