4-Hydroxy-2-(trifluoromethyl)pyrimidine

Base Information

• Chemical Name: 4-Hydroxy-2-(trifluoromethyl)pyrimidine
• CAS No.: 1546-80-1
• Molecular Formula: C5H3F3N2O
• Molecular Weight: 164.087
• Hs Code.: 29335990
• Mol file: 1546-80-1.mol

Synonyms:4-Pyrimidinol, 2-(trifluoromethyl)- (7CI,8CI);2-(Trifluoromethyl)pyrimidin-4-ol;4-Hydroxy-2-trifluoromethylpyrimidine;NSC53585;2-Trifluoromethyl-4-hydroxypyrimidine;4(1H)-Pyrimidinone,2-(trifluoromethyl)- (9CI);

Chemical Property of 4-Hydroxy-2-(trifluoromethyl)pyrimidine

Chemical Property:

• Appearance/Colour: White or cream-colored powder
• Vapor Pressure: 4.797mmHg at 25°C
• Melting Point: 168-171 °C
• Refractive Index: 1.456
• Boiling Point: 140.934 °C at 760 mmHg
• Flash Point: 39.036 °C
• PSA: 46.01000
• Density: 1.522 g/cm³
• LogP: 1.20100
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Hydroxy-2-(trifluoromethyl)pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45-37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxy-2-(trifluoromethyl)pyrimidine

There total 5 articles about 4-Hydroxy-2-(trifluoromethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-2-trifluoromethylpyrimidine (24903-69-3) → 2-trifluoromethyl-4-hydroxypyrimidine (1546-80-1)

Guidance literature:

With hydrogen bromide; at 60 - 70 ℃; for 5h;

Reference yield:

2-trifluoromethyl-4,6-dihydroxypyrimidine (672-47-9) → 2-trifluoromethyl-4-hydroxypyrimidine (1546-80-1)

Guidance literature:

Multi-step reaction with 4 steps

1: trichlorophosphate; triethylamine / 4 h / 5 - 105 °C

2: methanol / 5 h / 0 - 35 °C

3: palladium 10% on activated carbon; hydrogen; triethylamine / 15 h / 25 - 35 °C / 760.05 Torr

4: hydrogen bromide / 5 h / 60 - 70 °C

With palladium 10% on activated carbon; hydrogen bromide; hydrogen; triethylamine; trichlorophosphate; In methanol;

Reference yield:

4,6-dichloro-2-(trifluoromethyl)pyrimidine (705-24-8) → 2-trifluoromethyl-4-hydroxypyrimidine (1546-80-1)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 5 h / 0 - 35 °C

2: palladium 10% on activated carbon; hydrogen; triethylamine / 15 h / 25 - 35 °C / 760.05 Torr

3: hydrogen bromide / 5 h / 60 - 70 °C

With palladium 10% on activated carbon; hydrogen bromide; hydrogen; triethylamine; In methanol;

upstream raw materials:

2-trifluoromethyl-4,6-dihydroxypyrimidine

4,6-dichloro-2-(trifluoromethyl)pyrimidine

4-methoxy-2-trifluoromethylpyrimidine

Downstream raw materials:

4-chloro-2-(trifluoromethyl)pyrimidine

4-bromo-2-(trifluoromethyl)pyrimidine

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